Non-small Cell Lung Cancer Clinical Trial
Official title:
Determine MTD and to Evaluate PK, Safety/Tolerability and Efficacy Profiles of Antroquinonol (Hocena®) in NSCLC Patients Refractory to Conventional Treatment Modalities
A phase I study to determine the maximum tolerable dose (MTD) and to evaluate pharmacokinetic, safety/tolerability and efficacy profiles of antroquinonol (Hocena®) in non-small cell lung cancer (NSCLC) subjects refractory to conventional treatment modalities
1. Antroquinonol, a novel cyclohexenone compound, is a purified compound from extract of
Antrodia camphorata.
2. The pharmacological effects of antroquinonol were postulated to exert its
antitumorigenesis effects through interactions to primary targets of epidermal growth
factor receptor (EGFR)/Akt/mitogen-activated protein kinase (MAPK).
3. In vivo study in NOD/SCID mice with A549 subcutaneous xenografts consistently showed
tumor growth suppression after 2 weeks of oral 30 and 60 mg/kg antroquinonol treatment.
;
Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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