Non Small Cell Lung Cancer Clinical Trial
Official title:
A Prospective Non-randomized Study of 131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiotherapy (EBRT) and Concurrent Chemotherapy in Patients With Inoperable, Locally-advanced (Stage III) NSCLC
The aim of this feasibility study is to determine the therapeutic potential of the L19SIP
antibody, labeled with the radionuclide 131I in combination with radiochemotherapy, for the
treatment of patients with newly diagnosed, unresectable, locally-advanced NSCLC following
the promising results with this agent in previous clinical studies.
The L19SIP antibody is a fully human antibody, capable of preferential localization around
tumor blood vessels while sparing normal tissues. The formation of new blood vessels is a
rare event in the adult (with the exception of the female reproductive tract), but it is a
characteristic pathological feature for most types of aggressive cancer.
n/a
Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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