Non-Small Cell Lung Cancer Clinical Trial
Official title:
An Exploratory, Prospective Phase II Study to Investigate Progression-Free Survival, Response and Overall Survival Seen With Pemetrexed/Cisplatin and the Role of Thymidylate Synthase Expression
Thymidylate synthase (TS) is a substance the body produces naturally. The purpose of this research is to determine if there is a link between TS production and how well patients respond to treatment of non-squamous non-small cell lung cancer (NSCLC). The aim for the future is that doctors could have a better understanding in advance about which patients might respond well to pemetrexed based on how much TS they produce.
All patients on this study will receive 4 intravenous injections of the chemotherapy drugs
pemetrexed and cisplatin (with each injection approximately 3 weeks apart). Patients who
complete 4 such injections and respond well to their treatment may continue to receive an
injection of chemotherapy drug pemetrexed (approximately every 3 weeks). In general terms,
treatment will last until either the patient or the doctor decides that there is no clear
benefit in continuing with the treatment.
TS levels will be measured from the tumour sample used to make the original diagnosis of
NSCLC.
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Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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