Non Small Cell Lung Cancer Clinical Trial
Official title:
A Phase II Trial of Carboplatin, Bevacizumab and Pemetrexed in Advanced Non-Small Cell Lung Cancer
The purpose of this study is to look for an improvement in progression free survival with the combination of bevacizumab, carboplatin and pemetrexed in patients with newly diagnosed advanced/metastatic non small cell lung cancer. Overall survival and safety will also be assessed.
Carboplatin: AUC 5 IV over 30-60 minutes on day 1 Pemetrexed: 500mg/M2 IV over 10 minutes on
day 1 Bevacizumab: 15mg/kg IV over 90 minutes on day 1 (if rate is tolerated the 2nd dose may
be decreased to 60 minutes and subsequent doses to 30 minutes This regimen will be
administered every 6 weeks for up to a maximum of 6 cycles if the patient tolerates the
treatment and has stable disease. Bevacizumab will be continues if tolerated for up to 1 year
at every 3 week intervals.
Folic acid 1mg by mouth daily, Vitamin B12 1000 ug IM every 9 weeks and Dexamethasone 4mg by
mouth twice a day and and antiemetic may be prescribed by the physician investigator to help
reduce side effects associated with the Pemetrexed. The Folic acid and Vitamin B12 will
continue until 3 weeks after the end of treatment.
Physical exams, vital signs and blood work will be done prior to each chemotherapy cycle. A
urine dipstick to check for protein in the urine will be done prior to the first treatment
and before cycles 3 and 5. A CAT scan of the chest will be done pretreatment, prior to cycles
3 and 5 and at the end of treatment.
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