Non-small Cell Lung Cancer Clinical Trial
Official title:
A Phase II Trial of Adjuvant Erlotinib in Patients With Resected, Early Stage Non-Small Cell Lung Cancer (NSCLC) With Confirmed Mutations in the Epidermal Growth Factor Receptor (EGFR)
In this research study erlotinib will be given to eligible participants whose lung cancer has
been removed by surgery. Eligible patients have adenocarcinoma, a type of non-small lung
cancer, and must have 1 or more of the following characteristics: be female, be of Asian or
Pacific Rim descent and/or be a never smoker. The potential participant's tumor will be
examined for Epidermal growth factor (EGFR) mutations. EGFR is a protein that is
overexpressed in most non-small cell lung cancers. Some EGFR has been found to have specific
mutations and the participant must have one of these mutations in his tumor.
Erlotinib blocks this protein and may control tumor growth and increase survival. Previous
research has shown that erlotinib is most effective for people who have these specific
mutations in the EGFR.
- Erlotinib is a pill taken daily and participants may continue to receive erlotinib for
up to two years, as long as the cancer does not return and they do not experience any
unacceptable side effects.
- While participants are receiving erlotinib, they will be asked to return to the clinic
for study visits to monitor the status of their disease and their general health. For
the first 5 months of erlotinib, they will return to the clinic monthly. After that they
will return to the clinic every three months.
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