Temodar Plus Tyrosine Kinase Inhibitors for Progressive CNS Disease

Status Completed

Clinical Trial Summary

This trial is testing two novel combinations (temozolomide plus osimertinib OR temozolomide plus lorlatinib) which have not been evaluated in clinical trials. Thus, the exact benefits of these novel combinations are unclear. However, based on the mechanism of action of temozolomide and CNS(Central Nervous System) penetration/activity in other tumor types, it is hypothesized that adding temozolomide to osimertinib or temozolomide to lorlatinib may provide improvement in CNS disease control in patients with CNS progression on either of these latter two TKIs (Tyrosine kinase inhibitors).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04541407
Study type	Interventional
Source	University of Colorado, Denver
Contact
Status	Completed
Phase	Phase 1
Start date	October 29, 2020
Completion date	June 7, 2022

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