Safety Study of NHL With 90Y-hLL2 IgG

Status Completed

Clinical Trial Summary

This will be an open label, multiple center, non-randomized, dose-escalation Phase I/II trial, designed to evaluate the safety and effectiveness of a repeated, outpatient regimen utilizing IMMU-hLL2 intact monoclonal antibody IgG labeled with different doses of 90Y for the treatment of patients B-cell lymphoma (NHL).

Clinical Trial Description

90Y-labeled hLL2 will be administered according to a schedule based upon whether or not a patient had prior high-dose chemotherapy with a marrow or stem cell transplant. Patients with both indolent and aggressive types of NHL will be enrolled at each dose level without segregation. However, at the conclusion of the trial, with the maximum tolerated dose (MTD) defined, a minimum number of 6 patients with indolent NHL, 6 patients with aggressive NHL, and 6 patients with >25% bone marrow involvement will be studied at that dose level. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00421395
Study type	Interventional
Source	Gilead Sciences
Contact
Status	Completed
Phase	Phase 1/Phase 2
Start date	August 2002
Completion date	October 2007

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