Non-Hodgkin's Lymphoma (CD20+) Clinical Trial
Official title:
A Pilot Study of Rituximab in Combination With Out-patient Based VGF/F-GIV Salvage Therapies for Relapsed/Refractory CD20+ Lymphomas
This is a Phase II pilot study evaluating the safety of a risk-adjusted outpatient-based approach to lymphoma salvage therapy with VGF (vinorelbine, gemcitabine and pegfilgrastim) and/or F-GIV (gemcitabine, Ifosfamide, vinorelbine and pegfilgrastim) in combination with Rituximab (R-VGF/R-F-GIV).
Recent epidemiologic surveys have demonstrated a dramatic increase in the incidence of
non-Hodgkin's lymphoma (NHL). NHL is now one of the most rapidly increasing malignancies in
the industrial world.
The purpose of this project is to evaluate the efficacy and safety of an outpatient
treatment for relapsed or treatment resistant (refractory) CD20+ lymphoma. Two combinations
of chemotherapy drugs will be tested depending on the patients prior therapy and response -
rituximab, vinorelbine and gemcitabine (R-VGF) OR rituximab, vinorelbine, gemcitabine and
ifosfamide (R-FGIV).
Previous experience, including a recently completed study using combinations of vinorelbine,
gemcitabine and ifosfamide has demonstrated that such an outpatient approach is safe and of
similar efficacy to presently available alternative inpatient chemotherapy approaches. This
study is expanding on the findings from the previous study by adding rituximab.
Rituximab is being increasingly and successfully used in the therapy of CD20+ NHL. It is a
specific protein (antibody) that is directed against the surface protein (CD20 antigen)
found on CD20+ lymphoma cells and can therefore lead to the destruction of these cells.
Rituximab also has a highly favourable toxicity profile enabling outpatient treatment.
All of these factors provide a strong rationale for the combination of rituximab and the
novel outpatient-based salvage approaches VGF and F-GIV that we have recently evaluated.
This pilot study of 12 patients will test the feasibility of this combination approach in
patients with relapsed/refractory CD20+ NHL.
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Allocation: Non-Randomized, Endpoint Classification: Safety Study, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Treatment