Non Cardiac Surgery Clinical Trial
Official title:
Peri-Operative And Long-Term Cardioprotective Properties Of Sevoflurane In High Risk Patients Undergoing Non-Cardiac Surgery
Non-cardiac surgery is associated with significant cardiac morbidity and mortality. Volatile
anesthetics have a cardioprotective effects which results in preservation of left
ventricular function and lower troponin I levels. Lower troponin release has been correlated
with better long term event free survival in both cardiac and non cardiac surgery. A
recently completed meta-analysis suggests that sevoflurane is a superior volatile agent. The
evidence of a cardioprotective effect in non-cardiac surgery is lacking. Base on the current
literature, we intend to evaluate the protective potential of sevoflurane versus propofol
anesthesia in high risk patients undergoing elective non-cardiac procedures.
Hypothesis: The use of Sevoflurane as a general anesthetic reduces postoperative troponin
release, the incidence of myocardial infarction and/or long term morbidity in patients at
low to moderate risk of postoperative cardiac complications, who are undergoing noncardiac
surgery.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind
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