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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT02231333
Other study ID # ILBS-NASH-01
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date July 1, 2013
Est. completion date July 31, 2015

Study information

Verified date October 2019
Source Institute of Liver and Biliary Sciences, India
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Nonalcoholic fatty liver disease is one the most commonly encountered conditions in a daily outpatient Hepatology clinic. Secondly our country is the diabetic capital of the world and so the incidence of NAFLD (Non Alcoholic Fatty Liver Disease) is expected to rise in the future. It is a spectrum of hepatic pathology, ranging from simple steatosis, steatohepatitis, to cirrhosis. Nonalcoholic steatohepatitis (NASH) is a more advanced form of disease where steatosis is accompanied by hepatocyte injury as well as infiltration of inflammatory cells. Approximately 10-20% of patients with NASH may progress to cirrhosis. NASH is felt to be a major etiology of cryptogenic cirrhosis. Around 6230 human studies out of which 49 RCTs have been done till date to define the appropriate treatment of nonalcoholic steatohepatitis. However, still a controversy and no recommended treatment available till date. Recently published PIVENS trial has shown that Vitamin E has proven benefit in NASH. Other trials have also shown that pentoxiphylline has shown benefit in the form of histological improvement and biochemical improvement in the form of liver enzymes. Role of SAMe has been studied in alcoholic liver disease and showed to improve in both biochemical and histological features. However the usefulness of SAMe in NAFLD is not known till now. Hence this study has been designed.


Recruitment information / eligibility

Status Completed
Enrollment 122
Est. completion date July 31, 2015
Est. primary completion date July 31, 2015
Accepts healthy volunteers No
Gender All
Age group 18 Years to 70 Years
Eligibility Inclusion Criteria:

- Age 18 to 70 years

- Persistently abnormal ALT >1.2 times upper limit of normal

- Histological evidence of NASH (Non alcoholic Steatohepatitis) on liver biopsy. The minimal criteria for diagnosis of NASH included the presence of lobular inflammation and fibrosis up to stage 3 as per Burnt stating.

Exclusion Criteria:

- Alcohol intake of more than 40gm / week with features suggestive chronic liver disease .

- Other known cause of chronic liver disease like Hepatitis B,C, autoimmune liver disease, Wilson's disease, alpha 1 antitrypsin deficiency and hemochromatosis, primary biliary cirrhosis, PSC (Primary Sclerosis Cholangitis).

- Patient on Medication like estrogens, amiodarone, MTx, tamoxifen, ATT (Antitubercular Treatment)

- Pregnancy or lactation

- Hypersensitivity to methylxanthines (e.g., caffeine, theophylline,)

- Recent retinal/cerebral hemorrhage

- Acute myocardial infarction or severe cardiac arrhythmias.

- Impaired renal function.

Study Design


Related Conditions & MeSH terms


Intervention

Drug:
S-adenosylmethionine (SAMe)

pentoxiphylline (PTX)


Locations

Country Name City State
India Institute of Liver & Biliary Sciences New Delhi Delhi

Sponsors (1)

Lead Sponsor Collaborator
Institute of Liver and Biliary Sciences, India

Country where clinical trial is conducted

India, 

Outcome

Type Measure Description Time frame Safety issue
Primary Biochemical improvement in the form of AST/ALT 1 Years
Primary Improvement in LSM (Liver Stiffness Measurement) & CAP (Controlled Attenuation Parameter) 1 years
Secondary Metabolic response in form of anthropometry. metabolic response in form of anthropometry (BMI, waist circumference). 1 Years
Secondary Fasting lipid profiles 1 Years
Secondary Reduction in uric acid levels 1 Years
Secondary Reduction in pro- inflammatory cytokines 1 Years
Secondary Histological outcome in the form of improvement or non- progression in hepatocyte injury and fibrosis. 1 years
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