No Evidence of Disease Clinical Trial
Official title:
Clinical Protocol for an Open Label Study of Celecoxib (SC-58635) on the Acute Effect of Human UV-Irradiation
This clinical trial studies celecoxib in decreasing the damaging effects of sunburn in healthy volunteers. Celecoxib may reduce skin damage by blocking enzymes associated with sunburn in healthy volunteers.
PRIMARY OBJECTIVES:
I. Quantify changes in the erythema response in human subjects exposed to a range of
erythemic doses of solar-simulated ultraviolet light before and after celecoxib treatment.
II. Collect blood for genetic analysis of markers likely to modulate erythema response. This
includes cyclooxygenase (COX), prostaglandin receptor, P53 and excision-repair
polymorphisms.
OUTLINE:
Participants undergo ultraviolet (UV)-irradiation to the right buttock at baseline, receive
celecoxib orally (PO) twice daily (BID) for 10 days, and then undergo UV-irradiation to the
left buttock. Chromameter readings are obtained 24 hours post UV-irradiation.
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Prevention
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