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Concurrent Bupropion / Varenicline for Smoking Cessation — ConNic4  

Nicotine Dependence Clinical Trial

Official title:
Concurrent Bupropion / Varenicline for Smoking Cessation

Clinical Trial Summary

This study focuses on the first step in developing an algorithm for maximizing quit-smoking success based on an adaptive approach, which changes treatment from the initial nicotine replacement therapy (NRT) when that treatment alone may not be sufficient. These NRT "non-responders" are switched (in double-blind fashion) before the quit date to receive either varenicline alone or varenicline paired with bupropion. Some participants who would otherwise have failed at their quit smoking attempt could be "rescued" by switching to alternative pharmacotherapies. The proposed study will evaluate the combination treatment against varenicline alone in an adaptive trial design

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01303861
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 3
Start date March 2011
Completion date July 2013
View Details
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