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Improving the Efficacy of Anti-Nicotine Immunotherapy — PETNic002  

Nicotine Dependence Clinical Trial

Official title:
Improving the Efficacy of Anti-Nicotine Immunotherapy

Clinical Trial Summary

The purpose of this study is to find out how vaccine-induced antibodies change the way the body processes nicotine from cigarettes. These antibodies absorb nicotine and can reduce nicotine levels in the brain. In this way, the vaccination may help to quit smoking. The central hypothesis is that anti-nicotine antibodies change kinetics of brain nicotine accumulation and distribution of nicotine between the brain and other body tissues. This vaccine is investigational which means that it is still being tested in research studies and is not approved by the U.S. Food and Drug Administration (FDA) to help people quit smoking.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01280968
Study type Interventional
Source Duke University
Contact
Status Completed
Phase Phase 2
Start date December 2010
Completion date April 2013
View Details
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