Antibiotics Management of Septic Neutropenic Patients in the Intensive Care Unit

Neutropenia, Febrile Clinical Trial

— REANEUF  

Official title:

Antibiotics Management of Septic Neutropenic Patients in the Intensive Care Unit : New Recommendations do They Change Our Clinical Practice ?

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03217721
• Other study ID #: 29BRC17.0092
• Status: Completed
• Phase: N/A
• First received: July 5, 2017
• Last updated: September 29, 2017
• Start date: June 19, 2017
• Est. completion date: September 19, 2017

Study information

• Verified date: July 2017
• Source: University Hospital, Brest
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Neutropenia, defined by an absolute count of polymorphonuclear neutrophils less than <1500/mm3, exposes patients to infectious complications that can lead to sepsis or septic shock. The mortality risk is higher risk. The recommendations published in 2016 were formulated to homogenize the clinical practices to improve the survival.

Description:

We evaluate the adequacy antibiotics prescriptions in febrile neutropenia with suspected infection and evaluate factors influencing adequacy therapy and mortality consequence.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 100
• Est. completion date: September 19, 2017
• Est. primary completion date: September 19, 2017
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Sepsis or septic shock at admission or during the stay

Exclusion Criteria:

• Minor

• Pregnancy

• Opposition

Related Conditions & MeSH terms

• Febrile Neutropenia
• Neutropenia
• Neutropenia, Febrile

Locations

Country	Name	City	State
France	CHRU de Brest	Brest

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Brest

Country where clinical trial is conducted

France, 

References & Publications (1)

Schnell D, Azoulay E, Benoit D, Clouzeau B, Demaret P, Ducassou S, Frange P, Lafaurie M, Legrand M, Meert AP, Mokart D, Naudin J, Pene F, Rabbat A, Raffoux E, Ribaud P, Richard JC, Vincent F, Zahar JR, Darmon M. Management of neutropenic patients in the intensive care unit (NEWBORNS EXCLUDED) recommendations from an expert panel from the French Intensive Care Society (SRLF) with the French Group for Pediatric Intensive Care Emergencies (GFRUP), the French Society of Anesthesia and Intensive Care (SFAR), the French Society of Hematology (SFH), the French Society for Hospital Hygiene (SF2H), and the French Infectious Diseases Society (SPILF). Ann Intensive Care. 2016 Dec;6(1):90. doi: 10.1186/s13613-016-0189-6. Epub 2016 Sep 15. Review. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Proportion of adequate antibiotic prescription	Proportion of adequate antibiotic prescription	Through study completion, an average of 1 month
Secondary	Mortality of all causes	Mortality of all causes	ICU, hospital and 28-day mortality