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Clinical Trial Summary

The objective of this study is to compare the safety and efficacy of RGN-259 to placebo for the treatment of Neurotrophic Keratopathy (NK)


Clinical Trial Description

Neurotrophic keratopathy (NK) is a degenerative corneal disease that occurs as a result of partial or total impairment of trigeminal innervation. The resulting loss of corneal sensitivity (anesthesia) leads to a reduction in lacrimation and a decline in status, metabolism, and mitosis of corneal epithelial cells. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05555589
Study type Interventional
Source ReGenTree, LLC
Contact Shinwook Kang
Phone 609-734-4328
Email swkang@regentreellc.com
Status Recruiting
Phase Phase 3
Start date April 11, 2023
Completion date November 30, 2024

See also
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Completed NCT04293549 - An 8-week Follow-up to Evaluate the Renewal of Corneal Nerves Structure and Function in Patients With Neurotrophic Keratopathy Treated With Recombinant Human Nerve Growth Factor (rhNGF) Eyedrops
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Terminated NCT03084861 - A Clinical Trial to Asses Efficacy and Safety of Cord Blood Eye Drops in Neurotrophic Keratopathy Phase 1/Phase 2
Active, not recruiting NCT06411145 - Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis Phase 4
Not yet recruiting NCT06331910 - Efficacy and Safety of Topical Insulin for Neurotrophic Corneal Ulcers Phase 4