The Brain Activation During Different Motor Patterns in Healthy Adults

Neurosciences Clinical Trial

Official title:

The Brain Activation During Motor Execution, Motor Imagery, Action Observation, and Mirror Visual Feedback in Healthy Adults

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04868929
• Other study ID #: 202102037RINA
• Status: Completed
• Start date: May 1, 2021
• Est. completion date: August 7, 2022

Study information

• Verified date: June 2022
• Source: National Taiwan University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

This study aims to investigate the brain activation during different motor patterns, including motor execution (ME), motor imagery (MI), action observation (AO) and mirror visual feedback (MVF). In addition, the relations between brain activation and motor performance will also be explored. This study includes two parts, which are upper limb and lower limb part. While executing all the tasks, brain activation in primary motor cortex(M1), premotor cortex(PMC), and supplementary motor cortex(SMA) will be monitored by functional near-infrared spectroscopy. One-way ANOVA with repeated measure will be used to detect the differences of brain activation level between each mode. Pearson correlation coefficient will be used to determine the relations of brain activation and motor performance.

Description:

In upper limb part, subjects will be instructed to execute functional reaching task in ME, MI, AO, and MVF mode. During ME mode, motor performance including maximum speed, maximum acceleration, and jerk will be collected simultaneously. In the lower limb part, subjects will be instructed to walking over ground in ME, MI, and AO mode. During ME mode, the temporal and spatial gait parameters, including speed, stride time, cadence, and stride length will be collected.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 43
• Est. completion date: August 7, 2022
• Est. primary completion date: August 7, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 20 Years to 30 Years

Eligibility

• Inclusion Criteria

1. Age between 20 to 30 years.

2. Right-handed.

3. Ability to walk 30 meters independently without an assistive device.

4. No neurogical, cardiopulmonary, or muscle diseases that might interfere with the experiment.

5. Mini-Mental State Examination (MMSE) score greater than 24.

• Exclusion Criteria 1. Physiological condition is unstable.

Related Conditions & MeSH terms

• Neurosciences

Locations

Country	Name	City	State
Taiwan	National Taiwan University Hospital	Taipei

Sponsors (1)

Lead Sponsor	Collaborator
National Taiwan University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain activities over primary motor cortex	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.	Day 1
Primary	Brain activities over premotor cortex	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.	Day 1
Primary	Brain activities over supplementary motor area	A multichannel wearable fNIRS imaging system (NIRSport2, NIRx Medical Technologies LLC, Glen Head, NY, USA) is used to detect the hemodynamics.	Day 1
Secondary	Motor performance of upper limb -maximum speed	cm/s	Day 1
Secondary	Motor performance of upper limb -maximum acceleration	cm/s^2	Day 1
Secondary	Motor performance of upper limb - jerk	cm/s^3	Day 1
Secondary	Motor performance of lower limb - gait speed	cm/s	Day 1
Secondary	Motor performance of lower limb - cadence	steps	Day 1
Secondary	Motor performance of lower limb - stride time	second	Day 1
Secondary	Motor performance of lower limb - stride length	cm	Day 1