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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT03485066
Other study ID # PSY-NIL-0005
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date May 1, 2017
Est. completion date November 1, 2020

Study information

Verified date September 2019
Source Medical University of Vienna
Contact Rupert Lanzenberger, Assoc Prof
Phone +43140400
Email rupert.lanzenberger@meduniwien.ac.at
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Background: Neuronal plasticity is the brain's ability to continuously adapt to experiences and learning of new skills. Although this affects multiple characteristics of the brain such as structure, function and metabolism, direct interactions between these aspects are largely missing.

Aim: Using recent advancements in neuroimaging we aim to identify novel relationships how neuronal plasticity is related across these characteristics.

Design: 40 healthy subjects will undergo two simultaneous PET/MR measurements at baseline and after 4 weeks. During the measurements a cognitively challenging task will be performed and the training group (20 subjects) will practice during the 4-week period.

Implications: We combine simultaneous PET/MR and novel task-specific PET imaging to study brain metabolism, structure and function in a single measurement session. This provides optimal sensitivity for assessment of multimodal neuroplasticity associations. Knowledge how cognitive training affects multiple characteristics of the brain will also increase our understanding of disorders like depression, dementia and brain injuries, since these are diagnosed with cognitive evaluations. Considering the vast usage of the applied imaging procedures in diagnosis and therapy monitoring, the thorough investigation of multimodal associations offers benefit for the interpretability of neuroimaging in clinical routine.


Description:

Methodological details: Each subject will undergo two PET/MR examinations. Imaging will include PET as well as acquisition of structural and functional MRI. Task-specific glucose metabolism will be quantified with the radioligand [18F]FDG. Gray matter volume and white matter microstructure will be assessed with T1-weighted and diffusion weighted MRI, respectively. Functional imaging will focus on functional connectivity during rest and task as well as cerebral blood flow as acquired with ASL.


Recruitment information / eligibility

Status Recruiting
Enrollment 40
Est. completion date November 1, 2020
Est. primary completion date November 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 21 Years to 30 Years
Eligibility Inclusion Criteria:

- Age range 21-30 years

- Right-handedness

- Willingness and competence to sign the informed consent form

Exclusion Criteria:

- History of or current physical, neurological or psychiatric disorder

- History of or current substance abuse or medication including antipsychotic, antidepressant and antianxiety agents

- Pregnancy or current breastfeeding

- Contraindications for MRI-scanning (e.g., metal implants, steel grafts, etc), including dental implants causing signal artifacts

- For subjects participating in earlier studies using ionizing radiation, the total radiation exposure of 30mSv over the last 10 years must not be exceeded, as specified in the Austrian legislation on radiation protection

- Regular players of the video game Tetris (3 years before scanning).

- Failure to comply with the study protocol or to follow the instructions of the investigating team

Study Design


Related Conditions & MeSH terms


Intervention

Behavioral:
Tetris
The video game Tetris is a cognitively challenging task, which requires mental rotation, problem solving and fast visuo-spatial and motor coordination.

Locations

Country Name City State
Austria Department of Psychiatry and Psychotherapy, Medical University of Vienna Vienna

Sponsors (1)

Lead Sponsor Collaborator
Rupert Lanzenberger

Country where clinical trial is conducted

Austria, 

Outcome

Type Measure Description Time frame Safety issue
Primary Training induced changes in imaging parameters Imaging parameters are glucose metabolism ([18F]FDG PET), cerebral blood flow (arterial spin labeling MRI), functional connectivity (resting-state and task fMRI), gray matter volume (T1-weighted MRI) and white matter structure (diffusion weighted MRI) 4 weeks
Secondary Cognitive performance Training induced changes in performance of the video game (score per minute) 4 weeks
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