Neuromuscular Blockade Clinical Trial
Official title:
Pharmacokinetics of Rocuronium (1 mg/kg) for Deep Block : a Prospective Observational Study
Rocuronium is a non-depolarising neuromuscular blocking agent. The compound has a rapid onset
and an intermediate duration of action.
The rapid onset is of importance in patients at risk for pulmonary aspiration, for elective
induction of anesthesia. Clinical studies simulating rapid sequence induction in elective
patients indicate that rocuronium 0.9 mg kg-1 may be suitable for crash intubation.Also,
rocuronium may be an alternative to succinylcholine for rapid sequence induction when high
dose is injected (3x Effective Dose 95 %= 1mg/kg). But, pharmacokinetic of rocuronium at 1
mg/kg is not well establish.
The investigator investigate the onset and recovery of a single dose rocuronium (1 mg/kg) in
consecutive patients (>100) using adductor muscle monitoring (Train of Four and Post Tetanic
Count)
In this study, pharmacokinetic of rocuronium at 1 mg/kg will be evaluated at each point of
Train of Four Response (TOF) and Post Tetanic Count (when TOF=0) troughout the period of
anesthesia and surgery.
Time 0 is the time of rocuronium injection, Time 1 is the time when post tetanic count is >
5-7 and TOF=0, Time 3 when TOF >0 response, Time 4 when 4 reponses of the TOF and Time 5 when
TOF > 90 %
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