Neuromuscular Blockade Clinical Trial
Official title:
Assessment of Residual Paralysis in Patients in the Postoperative Anaesthetic Care Unit (PACU)
The purpose of this study is to assess the incidence of residual block in patients arriving in the Post Anaesthetic Care Unit (PACU) following surgery, and in those who have received neuromuscular blocking drugs (muscle relaxants). Residual block (decreased motor function) due to residual levels of muscle relaxants is associated with increased morbidity.
Status | Recruiting |
Enrollment | 400 |
Est. completion date | August 18, 2017 |
Est. primary completion date | August 18, 2017 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 21 Years to 99 Years |
Eligibility |
Inclusion Criteria: - All patients 21 years old or older, who receive neuromuscular blocking drugs (muscle relaxants) as part of their anaesthesia for surgery. Exclusion Criteria: - Patients who have neuromuscular disease - Patients for whom applying train-of-four (to detect residual block) monitoring on their ulnar nerves is not possible |
Country | Name | City | State |
---|---|---|---|
Singapore | Singapore General Hospital | Singapore |
Lead Sponsor | Collaborator |
---|---|
Singapore General Hospital |
Singapore,
Brull SJ, Prielipp RC. Reversal of neuromuscular blockade: "identification friend or foe". Anesthesiology. 2015 Jun;122(6):1183-5. doi: 10.1097/ALN.0000000000000675. — View Citation
Plaud B, Debaene B, Donati F, Marty J. Residual paralysis after emergence from anesthesia. Anesthesiology. 2010 Apr;112(4):1013-22. doi: 10.1097/ALN.0b013e3181cded07. Review. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Evidence of residual block (train of four <0.9) after receiving neuromuscular block for anaesthesia for surgery | Train of four is measured at the adductor pollicis using TOF Watch acceleromyography | Within one hour of surgery |
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