Probing Neural Circuitry for the Control of Movement

Neurological Movement Disorders Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02150642
• Other study ID #: EK-11/2004 / PB_2016-00229
• Status: Completed
• Start date: May 2004
• Est. completion date: July 31, 2020

Study information

• Verified date: August 2022
• Source: University of Zurich
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The investigators are interested in examining 1) the basic organization of spinal and cortical circuitry for the control of movement and 2) the influence of injury of these circuits. To investigate the neuronal circuitry, the investigators use various types of mechanical or electrical stimulation of the limbs, transcranial magnetic stimulation of the cortex and galvanic vestibular stimulation in both uninjured human subjects and subjects with a neurological injury (such as spinal cord injury, or Parkinsons's disease).

Recruitment information / eligibility

• Status: Completed
• Enrollment: 250
• Est. completion date: July 31, 2020
• Est. primary completion date: July 31, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• control subjects: no neurological movement disorder

• patients: neurological movement disorder

Exclusion Criteria:

patients and control subjects:

• presence of any central psychiatric disorder that precludes subject from giving informed and voluntary consent

• presence of any cardiovascular conditions or limitations that restrict the ability to walk on a treadmill continuously for more than 20 minutes

• for the electrical stimulation examination, subjects with metal implants are also excluded

• for the TMS and GVS examination, subjects with the following conditions are excluded:

metal implants in the head, cardiac pacemakers, history of migraine headaches, history of major head injury, history of stroke, history of seizures, previous brain neurosurgery, unstable medical conditions, major psychiatric disorders, pregnancy -

Related Conditions & MeSH terms

• Movement Disorders
• Neurological Movement Disorders

Locations

Country	Name	City	State
Switzerland	University of Zurich	Zurich

Sponsors (1)

Lead Sponsor	Collaborator
University of Zurich

Country where clinical trial is conducted

Switzerland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Spinal reflex activity	Spinal reflex activity will be assessed by electrical nerve stimulation	one day