Neurological Complications Clinical Trial
Official title:
Impact of Pretreatment With Omega 3 Enriched Lipid Emulsion on Early Neurological Complications After Living Donor Liver Transplantation. A Randomized Controlled Trial>
To study the impact of pretreatment of living donor liver transplantation recipients with SMOF lipid on the incidence and severity of post-transplantation neurological complications in patients receiving tacrolimus based immunosuppression protocol
All patients included in the study will receive the same immuno-suppression protocol based
on tacrolimus and mycophenolate mofetil after the induction immuno-suppression during the
intra-operative period.
Patients will have a full history taking and full neurological examination 48 hours prior to
the designated operative date as a basal record.
the control group will not receive any lipid infusions at all the treatment group will
receive the study emulsion (SMOF lipid 20% - Fresenius Kabi) starting 48 hours before the
planned surgery day and will continue to receive it for 5 post-operative days by intravenous
infusion.
During the post-operative period. patients will be assessed daily by full neurological
examination as will as patient complaints (symptoms) related to neurological status for
diagnosis of any neurological conditions (complications) that might arise during the study
period.
Data will be analysed compared to the basal value in each group and between both control and
intervention groups using the appropriate statistical tests.
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