Clinical Trials Logo

Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT00060541
Other study ID # 030164
Secondary ID 03-N-0164
Status Recruiting
Phase
First received
Last updated
Start date June 4, 2003

Study information

Verified date June 10, 2024
Source National Institutes of Health Clinical Center (CC)
Contact Surgical Neurology Branch
Phone (301) 496-2921
Email snbrecruiting@nih.gov
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Objective: This protocol is designed to allow evaluation of participants neurosurgical disorders that receive care within the Surgical Neurology Branch. The participants will receive standard-of-clinical-care evaluation and treatment. The clinical data and samples generated during standard of care treatment will be collected as a part of this study. Study Population: Participants 4 years of age and older with neurosurgical-related conditions seeking care from, or referred to the Surgical Neurology Branch for evaluation are eligible for this protocol. Study Design: This is an observational study. Participants will receive standard-of- clinical-care evaluation and treatment for their neurosurgical condition. Clinical evaluation may include laboratory and radiological studies designed to aid in diagnosis or differential diagnosis of the participant s condition or to facilitate treatment. The evaluations may take place in the outpatient clinic areas or in the inpatient units. Some participants will receive standard-of-care medical or surgical treatment for their disorder. Clinical data, tissue samples or body fluids obtained during standard of care treatment, may be used for research. Additional genetic testing may be performed on subjects and their blood relatives if a genetic mechanism underlying the neurological disorder is suspected. Patients in this study may choose to consent to skin biopsies for research purposes, in which case they will sign an additional consent document for thesethis research procedure. Outcome Measures: No additional research outcome measures will be tracked in this study, as this study is collecting data for potential future use. All outcomes will be those of standard clinical evaluation and treatment. A clinical and research database will be kept of patient s diagnosis, progression, and treatment. Clinical database information may be reported or be used in other studies.


Description:

Objective: This protocol is designed to allow evaluation of participants neurosurgical disorders that receive care within the Surgical Neurology Branch. The participants will receive standard-of-clinical-care evaluation and treatment. The clinical data and samples generated during standard of care treatment will be collected as a part of this study. Study Population: Participants 4 years of age and older with neurosurgical-related conditions seeking care from, or referred to the Surgical Neurology Branch for evaluation are eligible for this protocol. Study Design: This is an observational study. Participants will receive standard-of- clinical-care evaluation and treatment for their neurosurgical condition. Clinical evaluation may include laboratory and radiological studies designed to aid in diagnosis or differential diagnosis of the participant s condition or to facilitate treatment. The evaluations may take place in the outpatient clinic areas or in the inpatient units. Some participants will receive standard-of-care medical or surgical treatment for their disorder. Clinical data, tissue samples or body fluids obtained during standard of care treatment, may be used for research. Additional genetic testing may be performed on subjects and their blood relatives if a genetic mechanism underlying the neurological disorder is suspected. Patients in this study may choose to consent to skin biopsies for research purposes, in which case they will sign an additional consent document for thesethis research procedure. Outcome Measures: No additional research outcome measures will be tracked in this study, as this study is collecting data for potential future use. All outcomes will be those of standard clinical evaluation and treatment. A clinical and research database will be kept of patient s diagnosis, progression, and treatment. Clinical database information may be reported or be used in other studies.


Recruitment information / eligibility

Status Recruiting
Enrollment 5000
Est. completion date
Est. primary completion date
Accepts healthy volunteers No
Gender All
Age group 4 Years to 99 Years
Eligibility - INCLUSION CRITERIA: 1. Participants must be age 4 and older. 2. Participants must seek care from, or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders) 3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated 4. For minors: a parent or legal guardian who is able to provide consent. For immediate blood relatives of subjects having genetic testing only: 5. Blood relative of a subject who is suspected to have a genetic mechanism underlying their neurological disorder (for genetic testing only). EXCLUSION CRITERIA: 1. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder 3.c. Participant Inclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples) 1. Participants must be age 4 and older. 2. Participants must seek care from or be referred to the Surgical Neurology Branch for evaluation and management of neurosurgical conditions (such as central nervous system tumors, peripheral nerve tumors, epilepsy, Parkinson s disease, movement disorders, Chiari syndrome, central nervous system malformations, and pain disorders) 3. For adults: able to provide informed consent or having a legally-authorized representative to provide consent, if incapacitated 4. For minors: a parent or legal guardian who is able to provide consent. 5. Be willing to consent for collection of clinical data or biological samples or their cryopreservation 3.D. Participant Exclusion Criteria for the cohort with processing of biological samples only (for those subjects who are only having skin biopsies and/or saliva samples) 1. Patients who are unable to undergo evaluation and treatment for a neurosurgical disorder 2. At the time of enrollment, subjects without an established diagnosis of a wellcharacterized disease entity with validated treatment algorithms. In such cases, proposed resource investment, in the opinion of the investigators, would not contribute to further advancement of knowledge

Study Design


Related Conditions & MeSH terms


Intervention

Procedure:
Laboratory tests

Radiological exams


Locations

Country Name City State
United States National Institutes of Health Clinical Center Bethesda Maryland

Sponsors (1)

Lead Sponsor Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)

Country where clinical trial is conducted

United States, 

Outcome

Type Measure Description Time frame Safety issue
Primary standard clinical evaluation and treatment standard clinical evaluation and treatment ongoing
See also
  Status Clinical Trial Phase
Terminated NCT02236091 - Monitoring Everyday Life Motor Activity in Children
Recruiting NCT02795052 - Neurologic Stem Cell Treatment Study N/A
Recruiting NCT04684602 - Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions Phase 1/Phase 2
Completed NCT02504840 - Natural History of Multiple Sclerosis and Its Mimickers
Completed NCT01581567 - Neuroimmunology Branch Repository
Recruiting NCT00271622 - The Neurodevelopmental and Behavioral Phenotyping Screening Protocol
Terminated NCT02527460 - Anakinra, A Recombinant Human IL-1 Receptor Antagonist for Neuroinflammation in HIV-1 Infection Phase 1
Active, not recruiting NCT00005557 - Epidemiology of Sleep-Disordered Breathing in Adults