Clinical Trials Logo

Clinical Trial Summary

Prospective, multi-site, single-arm study to evaluate the diagnostic yield of cWGS in adults with neurological disorders. A single cohort naive of genetic testing will receive standard of care testing for 180 days followed by cWGS. The cohort will be followed for a total of 365 days following enrollment.


Clinical Trial Description

This is a prospective, randomized study to evaluate the diagnostic yield of SOC compared to cWGS in each participant. Throughout this study, each participant will receive SOC testing as determined by the site clinical team. After the physician orders SOC testing during standard clinical practice, the subject will be introduced and invited to participate in the study. On Day 180, the participant will receive a cWGS result and the participant will continue to be followed for an additional 180 days. A blood sample from each enrolled participant will be collected and shipped to the Illumina Clinical Services Laboratory ("ICSL"), which is Clinical Laboratory Improvement Amendments (CLIA)-certified and College of American Pathologists (CAP)-accredited. ICSL will conduct cWGS testing with the TruGenome Undiagnosed Disease Test ("TruGenome Test"). The TruGenome Test cWGS results will be provided to the Principal Investigator (PI) or designee who will evaluate each participant's test outcome based on aggregate medical information. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04170985
Study type Observational
Source Illumina, Inc.
Contact
Status Completed
Phase
Start date November 18, 2019
Completion date January 31, 2024

See also
  Status Clinical Trial Phase
Not yet recruiting NCT05519592 - Proximal Lower Limb Intramuscular Block : Effects on Hemiparetic Gait N/A
Recruiting NCT04098679 - Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids)
Completed NCT03946137 - Chest Therapy and Postural Education in Children With Cerebral Palsy N/A
Completed NCT05217186 - Associations Between Early Neonatal Neuroimaging, Hammersmith Infant Neurological Examination and General Movements
Not yet recruiting NCT05506306 - Multitissular Effect of Vertical Mobilization Using the Exoskeleton AtalanteTM in Neurological Chair- or Bed-bound Patients
Recruiting NCT04846413 - Voice Analysis in Patients With Neurologic Diseases
Recruiting NCT05260190 - Manual Dexterity Modifications After Application of tSMS Over the Primary Motor Cortex (M1) N/A
Not yet recruiting NCT04906681 - Implementation of a Rehabilitation Technology in Orthopedic and Neurological Rehabilitation to Increase Therapy Dosage: an Exploratory Study Phase 1/Phase 2
Completed NCT04743037 - Interactive Self-Management Augmented by Rehabilitation Technologies N/A
Not yet recruiting NCT03899298 - Safety and Clinical Outcomes With Amniotic and Umbilical Cord Tissue Therapy for Numerous Medical Conditions Phase 1
Active, not recruiting NCT04631965 - Healthcare Transition of Adolescents With Chronic Health Conditions
Recruiting NCT05132517 - Magnesium and Cognition After Stroke
Recruiting NCT04100993 - Multisystem and Autonomic Complications of NMD on Long-term NIV
Recruiting NCT05652946 - IISART (International Industry Society of Advanced Rehabilitation Technology) Advanced Rehabilitation Technology Study N/A
Recruiting NCT06146543 - Stress Ball During Lumbar Puncture the Effect of the Application on Anxiety Level N/A
Completed NCT06368024 - Establishment of Delphi-MD Safety Performance and Reliability
Not yet recruiting NCT06169696 - EMPOWER Early Feasibility Study: Non-invasive BCI to Control a Wheelchair for People With Paralysis N/A
Completed NCT03329872 - Neuro-Orthopedic Registry of the University Hospital of Toulouse
Completed NCT05483244 - Weaning Success in Different Weaning Strategies in Early Neurological Rehabilitation Patients - a Matched-pair Analysis
Completed NCT04624347 - NEOVIDEO : Impact of Monitoring Motor Activity by Video Analysis on the Sleep of Very Preterm Infants N/A