Neurologic Disorder Clinical Trial
— CSM PlasticityOfficial title:
Plasticity of Chronically Compressive Spinal Cord After Surgical Decompression - A fMRI Study
NCT number | NCT03504254 |
Other study ID # | UW12-468 |
Secondary ID | |
Status | Completed |
Phase | |
First received | |
Last updated | |
Start date | January 11, 2012 |
Est. completion date | December 31, 2019 |
Verified date | September 2019 |
Source | The University of Hong Kong |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Observational |
Cervical myelopathy (CM), a chronically compressive spinal cord lesion, is the most common cause of non-traumatic paraparesis/quadriparesis among the elderly. Hong Kong is facing a heavy social economic burden from CM with the rapidly aging population. Surgical decompression is considered as the mainstay of the treatment for CM patients to relieve their symptoms and signs. Yet the surgical outcome is not always satisfactory. There is a pressing need for understanding the exact mechanism of surgical decompression on the recovery of myelopathic cord in order to improve the prognosis of CM patients in near future.This project will evaluate neuronal activities and axon regeneration by longitudinally monitoring at time zero, 3 and 6 month after the surgery in CM patients using UTE, BOLD-fMRI and DTI, and to investigate the relationship of preoperative neuronal activities of myelopathic cord with axon regeneration.
Status | Completed |
Enrollment | 50 |
Est. completion date | December 31, 2019 |
Est. primary completion date | November 30, 2019 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 90 Years |
Eligibility | Inclusion Criteria: - The inclusion criteria are a clinical diagnosis of CM including the signs of corticospinal lesion/s together with the appropriate radiographic findings. Exclusion Criteria: - Patients with acute spinal cord injuries, prior spinal intervention or claustrophobia will be excluded. |
Country | Name | City | State |
---|---|---|---|
Hong Kong | The university of Hong Kong | Hong Kong |
Lead Sponsor | Collaborator |
---|---|
The University of Hong Kong |
Hong Kong,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | DTI indics | The mean diffusivities and fractional anisotropy will be measured in the DTI | Change between Enrollment and one year after surgery. | |
Secondary | fMRI connextivity | Functional connectivity will be examined by calculating the averaged correlation coefficient of all regions of interest (ROIs) in gray matters. | Change between Enrollment and one year after surgery. |
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