Neuroendocrine Carcinoma Clinical Trial
Official title:
Phase II Study of the Combination of Bevacizumab, Pertuzumab, and Sandostatin for Patients With Advanced Neuroendocrine Cancers.
The purpose of this Phase II trial will be to define the activity of a VEGF inhibitor
bevacizumab, HER1/HER2 inhibitor pertuzumab, and sandostatin for patients with
advanced neuroendocrine cancers. In particular, the efficacy of bevacizumab and
pertuzumab treatment is of great interest. The primary endpoint of this trial will be
response rate. Toxicity and progression-free survival will be obtained and evaluated.
- To determine overall response rate of patients with low grade neuroendocrine cancer
when treated with the combination of bevacizumab, pertuzumab and sandostatin LAR®.
- To determine the disease control rate (objective response + stable disease), time to
treatment progression, progression-free survival, and overall survival in patients with
advanced low grade neuroendocrine cancer when treated with bevacizumab, pertuzumab and
Sandostatin LAR® treatment.
- To define the toxicity and safety of the combination of bevacizumab, pertuzumab and
Sandostatin LAR® when used in patients with advanced low grade neuroendocrine cancer.
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Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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