Neurodegenerative Diseases Clinical Trial
The diagnosis of neurodegenerative conditions and ADHD still mostly relies on clinical
symptoms as there are no validated, inexpensive, and simple bio- markers available yet. The
purpose of this study is to deliver a proof-of-concept for novel biomarkers to identify
neurodegenerative conditions and ADHD based on breath testing.
Alveolar breath will be collected from healthy volunteers, patients with extrapyramidal
conditions, patients diagnosed with dementia and from ADHD subjects. The discriminative
power of a tailor-made Nanoscale Artificial Nose (™NA-NOSE) containing an array of six
nanomaterial-based sensors will be tested. Discriminant factor analysis will be applied to
the NA-NOSE signals in order to detect statistically significant differences between the
sub-populations, and classification success will be estimated using leave-one-out
cross-validation. The identification of NA-NOSE patterns will be supported by analyzing the
chemical composition of the breath using gas-chromatography in conjunction with
mass-spectrometry (GC-MS).
n/a
Time Perspective: Prospective
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