Cognitive Functions on Coronary Surgery

Status Completed

Clinical Trial Summary

The aim of this study is to examine the effects of different but safe levels of arterial oxygen levels used in cardiac surgeries on cerebral oxygenation during the operation. It is also to investigate the effect on cognitive functions in the postoperative period. For our study the investigators will conduct a randomized control trial. Patients will be randomly assigned to one of two possible study groups according to the arterial oxygen levels.If there is any abnormality in cerebral oxygen levels during surgery, necessary intervention will be made by doctors.

Clinical Trial Description

In most cardiovascular surgeries, patients are frequently followed up at hyperoxemic level for safety purposes against the risk of tissue hypoxia that may develop during surgery due to CPB use. At the level of hyperoxemia, there are opinions that the ischemia-reperfusion damage increases with the follow-up of CABG surgery, microcirculation is impaired and tissue oxygenation is impaired due to the resulting hyperoxemic vasoconstriction. Recent research has focused on evaluating optimal oxygen levels in CPB during cardiac surgery. However, the potential of tightly regulated intraoperative normoxia to improve POCD following cardiac surgery has not been studied prospectively. The purpose of this study is to determine whether patients who underwent CPB and CABG, which were preserved under normoxic conditions during the intraoperative period, would have a lower incidence of early and late POCD than those exposed to hyperoxia. ;

Study Design

Related Conditions & MeSH terms

Neurocognitive Disorders

Clinical Trial Details

NCT number	NCT04725708
Study type	Interventional
Source	Bursa Yüksek Ihtisas Education and Research Hospital
Contact
Status	Completed
Phase	N/A
Start date	November 1, 2019
Completion date	August 1, 2020

View Details

See also
Status	Clinical Trial	Phase
Recruiting	`NCT05754567` - CONCEPTT Kids International Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes
Completed	`NCT05080777` - Pilot Pragmatic Clinical Trial to Embed Tele-Savvy Into Health Care Systems	N/A
Not yet recruiting	`NCT03276377` - VItamin K Inhibition and NeurocoGnition (VIKING)	N/A
Completed	`NCT04175223` - Impact of Probiotics in HIV-positive Patients With Neurocognitive Disorders	N/A
Completed	`NCT03538522` - A Double-Blind, Placebo-Controlled Safety and Efficacy Study of NA-831	Phase 2
Recruiting	`NCT05732285` - A Pilot Randomized Controlled Trial: CoINTEGRATE	N/A
Recruiting	`NCT04095962` - Effects of a Multicomponent Exercise Intervention on Physical and Cognitive Function of Older Adults With Dementia	N/A
Not yet recruiting	`NCT04113577` - COgilus Remediation in Alzheimer Patients (CORA)
Recruiting	`NCT06320639` - DRIVing Simulator and People With NeuroCognitive Disorders
Recruiting	`NCT06105320` - COGNIFOOD-Changing the Carbohydrate/Fat-ratio to Prevent Cognitive Decline and Alzheimer Pathology: A Pilot Study	N/A
Completed	`NCT03050385` - Cognitive Rehabilitation During Transcranial Direct Current Stimulation	N/A
Active, not recruiting	`NCT06372002` - Effectiveness and Cost-Effectiveness of Cognitive Stimulation Therapy - Spain (CST-ES) in People Living With Dementia	N/A
Recruiting	`NCT05508789` - A Study of Donanemab (LY3002813) in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ 5)	Phase 3
Recruiting	`NCT03926351` - High Dose Omega 3 in People at Risk for Dementia	Phase 2
Recruiting	`NCT05504681` - Integration of Neurocognitive Biomarkers Into a Neuro-Oncology Clinic
Completed	`NCT04168268` - Patient-reported Outcome Measures After Post-anesthesia Care Unit Delirium
Recruiting	`NCT04825847` - Neurocognitive Disorders After Major Surgery in Elderly	N/A
Active, not recruiting	`NCT02958670` - Imaging Tau Deposition in the Brain of Elderly Subjects	N/A
Enrolling by invitation	`NCT02652598` - Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With BI and NCD	Phase 2
Completed	`NCT02825732` - MEMORA-Caregiver : Risk Factors of Caregiver Burden Among Patients With Neurocognitive Disorders or Subjective Cognitive Complaint	N/A