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Clinical Trial Summary

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma.


Clinical Trial Description

Difluoromethylornithine (DFMO) will be used in an open label, multicenter, study in combination with etoposide for subjects with relapsed/refractory neuroblastoma. In this study subjects will receive six 21-day cycles of Etoposide and DFMO followed by an additional 630 days of DFMO alone. Subjects will be evaluated in 3 arms: • Arm 1: Subjects who show no active disease after receiving any additional therapy for neuroblastoma that was refractory to standard induction/consolidation therapy. Refractory: Subjects with progressive disease on upfront therapy OR did not have at least PR on induction OR required additional second line therapy to achieve remission who are now in first remission. - Arm 2: Subjects who have previously relapsed and currently show no active disease (in CR2 or greater). - Arm 3: Subjects who are relapsed or refractory with active disease. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04301843
Study type Interventional
Source Milton S. Hershey Medical Center
Contact Genevieve Bergendahl, MSN
Phone 7175310003
Email gbergendahl@pennstatehealth.psu.edu
Status Recruiting
Phase Phase 2
Start date September 25, 2020
Completion date October 1, 2033

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