Neuroblastoma Clinical Trial
Official title:
Genome Based Outcome Prediction in High Risk Neuroblastoma
RATIONALE: Studying samples of tumor tissue from patients with cancer in the laboratory may
help doctors learn more about changes that occur in RNA and predict how patients will
respond to treatment. It may also help doctors find better ways to treat cancer.
PURPOSE: This research trial studies gene expression in predicting outcomes in samples from
patients with high-risk neuroblastoma.
OBJECTIVES:
- To test the correlation of a previously published microarray gene expression signature
with the gene expression obtained with the nCounter™ Analysis System using RNA isolated
from formalin-fixed, paraffin-embedded (FFPE), high-risk neuroblastoma samples.
- To construct, test, and validate a novel robust classifier that can be readily
integrated into the clinic.
OUTLINE: This is a multicenter study.
RNA samples extracted from paraffin-embedded tissue are analyzed for gene signature
expression levels by nCounter™ Analysis System and correlated with published microarray
expression data. Results are then used to develop a refined gene-expression-profile
classifier of ultra high-risk neuroblastoma.
;
Observational Model: Cohort, Time Perspective: Retrospective
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