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NCT01407731 Clinical Trial

Protein Expression in Human Neuroblastoma Tumor Samples

Neuroblastoma Clinical Trial

Official title:
Analysis of Intersectin Expression in Primary Human Neuroblastomas

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT01407731
Other study ID # ANBL11B4
Secondary ID COG-ANBL11B4ANBL
Status Active, not recruiting
Phase N/A
First received July 30, 2011
Last updated May 8, 2015
Start date July 2011

Study information
Verified date May 2015
Source Children's Oncology Group
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

RATIONALE: Studying protein expression in samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors find better ways to treat neuroblastoma.

PURPOSE: This laboratory studying is looking at protein expression in tumor tissue samples from patients with neuroblastoma.

Description:

OBJECTIVES:

- To determine whether intersectin (ITSN1) proteins are present at elevated levels in primary human tumor samples.

OUTLINE: Archived tumor tissue samples are analyzed for intersectin (ITSN1) expression by western blot assays with enhanced chemiluminescence and exposed to X-ray film. The films are scanned, and levels of ITSN1 signal are quantified by densitometry.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 20
Est. completion date
Est. primary completion date January 2100
Accepts healthy volunteers No
Gender Both
Age group N/A and older
Eligibility DISEASE CHARACTERISTICS:

- Diagnosed with neuroblastoma

- Banked primary tumor samples from patients with stage 1, 2, 3, and 4 disease

PATIENT CHARACTERISTICS:

- Not specified

PRIOR CONCURRENT THERAPY:

- Not specified

Study Design

Observational Model: Case-Only, Time Perspective: Retrospective

Related Conditions & MeSH terms

Intervention

Genetic:
• protein expression analysis

• western blotting

Other:
• laboratory biomarker analysis

Locations
Country Name City State
n/a

Sponsors (2)
Lead Sponsor Collaborator
Children's Oncology Group National Cancer Institute (NCI)

Outcome
Type Measure Description Time frame Safety issue
Primary ITSN1 is highly expressed in neuroblastoma tumors and plays an important role in the development/progression of these tumors No
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