Neuroblastoma Clinical Trial
Official title:
A Pharmacokinetic-Guided Phase II Trial of the Rebeccamycin Analog NSC# 655649 in Pediatric Patients With Relapsed/Refractory Neuroblastoma
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing
so they stop growing or die.
PURPOSE: Phase II trial to study the effectiveness of rebeccamycin analog in treating
children who have relapsed or refractory neuroblastoma.
OBJECTIVES:
- Determine the response rate to rebeccamycin analogue in children with relapsed or
refractory neuroblastoma.
- Determine the toxicity of this drug in these patients.
- Identify and establish in vitro biologic correlates of clinical responses and toxicity
of this drug in these patients.
OUTLINE: Patients receive rebeccamycin analogue IV over 1 hour once on days 1-5. Treatment
repeats every 3 weeks for at least 2 courses in the absence of disease progression or
unacceptable toxicity.
PROJECTED ACCRUAL: This study will accrue up to 30 patients within 1.5 years.
;
Primary Purpose: Treatment
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