Effects of Intense Exercise on Neural Responses to Food.

Neural Responses Clinical Trial

Official title:

The Effects of High Intensity Exercise on Neural Responses to Images of Food

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01926431
• Other study ID #: fMRI Study
• Secondary ID: ERN_09-586
• Status: Completed
• Phase: N/A
• First received: August 20, 2013
• Last updated: August 20, 2013
• Start date: September 2009
• Est. completion date: May 2011

Study information

• Verified date: August 2013
• Source: University of Birmingham
• Contact: n/a
• Is FDA regulated: No
• Health authority: United Kingdom: Research Ethics Committee
• Study type: Interventional

Clinical Trial Summary

The primary aim of this study was to determine the effects of an acute bout of high intensity exercise on the brains response to viewing pictures of food using functional magnetic resonance imaging (fMRI).

Description:

It is clear that intense exercise impacts on peripheral appetite regulation, however very little is known about the impact of high-intensity exercise on central appetite regulation. This study aimed to investigate the effects of high-intensity exercise on both central and peripheral responses to images of food. Functional magnetic resonance techniques were used to assess the brains response to images of high and low calorie foods, following a short bout of high-intensity exercise. Appetite hormone concentrations were also measured. It was hypothesized that, due to the known effects of high-intensity exercise on appetite regulatory hormones and subjective appetite ratings, the activation of reward-related brain regions to visual food cues would be modulated following intense physical activity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 16
• Est. completion date: May 2011
• Est. primary completion date: May 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 30 Years

Eligibility

Inclusion Criteria:

• Healthy, non-smokers, free from cardiovascular disease and metabolic disease, no medication, participated in moderate/vigorous physical activity (>2 hours per week)

Exclusion Criteria:

• Smokers, history of cardiovascular/metabolic disease, low physical activity levels, inability to participate in fMRI scanning sessions including contraindications to MRI

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Appetite Hormones
• Neural Responses
• Subjective Appetite Sensations

Intervention

Other:
• Exercise

• Rest

Locations

Country	Name	City	State
United Kingdom	Birmingham University Imaging Centre	Birmingham	Midlands

Sponsors (1)

Lead Sponsor	Collaborator
University of Birmingham

Country where clinical trial is conducted

United Kingdom, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neural responses following exercise and rest	Volunteers completed an fMRI assessment following 60 minutes of intense exercise and 60 minutes of rest on two separate occasions.	Ten minutes post-exercise/rest	No
Secondary	Appetite hormones	Blood samples were taken using a cannula system for both trials. Concentrations of appetite regulating hormones were measured from plasma.	Blood samples taken at baseline, following exercise/rest, prior to the fMRI assessment and immediately following the fMRI assessment	No