Nervous System Neoplasms Clinical Trial
— NeuroVentOROfficial title:
Protective Ventilation in Neurosurgery, a Pilot Study
Verified date | November 2016 |
Source | IRCCS San Raffaele |
Contact | n/a |
Is FDA regulated | No |
Health authority | Italy: Ethics Committee |
Study type | Interventional |
The purpose of this study is to assess the effect size and variability of dural tension measured as intracranial pressure (ICP) below the dura of the surgical field in patients undergoing elective supra-tentorial surgery for brain neoplasms in patients alternatively ventilated with traditional high-volume-no-PEEP ventilation and protective low-volume-low-PEEP ventilation.
Status | Completed |
Enrollment | 40 |
Est. completion date | November 2016 |
Est. primary completion date | November 2016 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 18 Years to 80 Years |
Eligibility |
Inclusion Criteria: Elective surgical removal of a supra-tentorial neoplasm conditioning mass effect defined as: - Median line shift at preoperative CT scan = 5mm - Cortical brain effacement at preoperative CT scan Exclusion Criteria: - Age < 18 yrs or > 80 yrs. - BMI > 30 - Pregnancy. - Refusal to sign the informed consent. - Emergency surgery. - Respiratory co-morbidities (clinical evidence or history of COPD, asthma, interstitial pneumopathies, previous thoracic surgery). |
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
Italy | S. Raffaele Hospital | Milano | MI |
Lead Sponsor | Collaborator |
---|---|
IRCCS San Raffaele |
Italy,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Intracranial pressure measured in mmHg | Primary endpoint: to assess the effect size and variability of dural tension measured as intracranial pressure (ICP) below the dura of the surgical field in patients undergoing elective supra-tentorial surgery for brain neoplasms in patients alternatively ventilated with traditional high-volume-no-PEEP ventilation and protective low-volume-low-PEEP ventilation. | Outcome 1 is assessed before the incision of dura mater (mean 1 hour). | Yes |
Secondary | Dural tension measured by a two point scale (acceptable/unacceptable). | Secondary endpoints: subjective assessment of dural tension by the attending neurosurgeon quantified as "acceptable tension" or "unacceptable tension" at the end of crossover. | Outcome 2 is assessed before the incision of dura mater (mean 1 hour). | Yes |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
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