Nephropathy Clinical Trial
Official title:
The Effects of Tolvaptan on Renal Handling of Water and Sodium, Vasoactive Hormones and Circulatory System, During Basal Conditions and During Inhibition of the Nitric Oxide System in Healthy Subjects. A Dose-response Study.
Tolvaptan is a selective vasopressin receptor antagonist (V2R) that increases free water and
sodium excretion. Inhibition of V2R increases vasopressin concentration in plasma, which
stimulates V1-receptors in the vascular bed and may change both central and brachial
hemodynamics and plasma concentration of vasoactive hormones.
The purpose of the study is to measure the effects of tolvaptan on renal handling of water
and sodium, systemic hemodynamics and vasoactive hormones at baseline and during nitric
oxide (NO)-inhibition with L-NG-monomethyl-arginine (L-NMMA).
n/a
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