Clinical Trials Logo
  1. Home
  2. Nephrolithiasis
  3. NCT04367155
  4. Details
NCT04367155 Clinical Trial

Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.

Nephrolithiasis Clinical Trial

Official title:
Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy. a Double-blind, Placebo-controlled Randomized Clinical Trial.

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04367155
Other study ID # RS/19.22
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date September 1, 2019
Est. completion date March 1, 2022

Study information
Verified date March 2021
Source Kafrelsheikh University
Contact Diaa Eldin Taha, MD
Phone 01008531384
Email drdiaaeldin@gmail.com
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Efficacy of tranexamic acid on blood loss during percutaneous nephrolithotomy. a double-blind, placebo-controlled randomized clinical trial.

Description:

To evaluate whether intravenous tranexamic acid or tranexamic acid in the irrigation fluid in percutaneous nephrolithotomy (PCNL) in reducing bleeding during and after PCNL.

Recruitment information / eligibility
Status Recruiting
Enrollment 200
Est. completion date March 1, 2022
Est. primary completion date September 1, 2021
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Patient 18 years or older - Stones = 2 cm and/or mild to moderate hydronephrosis. Exclusion Criteria: - Age <18 years or Pregnancy - Bilateral simultaneous PCNL - Morbid obesity (BMI >40) - Refuse to complete study requirements - Untreated UTI - Atypical bowel interposition by CT - Tumour in the presumptive access tract area or Potential malignant kidney tumour

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Tranexamic acid injection
hemostatics use

Locations
Country Name City State
Egypt Kafrelsheikh faculty of medicine Kafr Ash Shaykh Kafrelsheikh

Sponsors (1)
Lead Sponsor Collaborator
Kafrelsheikh University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary To assess the value of tranexamic acid To compare the efficacy and safety of 0.1% IV tranexamic acid versus inside the irrigant fluid tranexamic acid in reducing blood loss during PCNL. Moreover, to assess the adverse events of tranexamic acid. 12 months
Secondary Hemoglobin drop post PCNL. Assess fall percentage in hemoglobin drop. 12 months
Secondary Requirement of blood transfusion post PCNL. assess the total blood loss and requirement of blood transfusion post PCNL. 12 months
See also
  Status Clinical Trial Phase
Enrolling by invitation NCT04746378 - PRedictive Accuracy of Initial Stone Burden Evaluation.
Recruiting NCT05100017 - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure N/A
Recruiting NCT03692715 - Antibiotic Prophylaxis Before Shock Wave Lithotripsy Phase 4
Completed NCT02547805 - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days Phase 2
Completed NCT02289755 - Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria Phase 2
Completed NCT01650935 - Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria N/A
Completed NCT01690039 - Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Completed NCT01295879 - Vitamin D Repletion in Stone Formers With Hypercalciuria Phase 4
Recruiting NCT05014178 - Kidney Sodium Functional Imaging
Not yet recruiting NCT06199102 - The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants. N/A
Recruiting NCT04374188 - Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy N/A
Recruiting NCT05701098 - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD) N/A
Recruiting NCT04389853 - Mini-PNCL vs fURS in Management of Nephrolithiasis N/A
Completed NCT03348228 - Effect of Hydroxycitrate on Urine Chemistry N/A
Completed NCT05350423 - Trial Assessing Renal Damage During Ureteroscopy N/A
Completed NCT03454139 - Subcostal TAP Block For Percutaneous Nephrolithotomy N/A
Recruiting NCT02279927 - Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy N/A
Completed NCT02276924 - Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors N/A
Completed NCT00159393 - Percutaneous Nephrolithotomy: A Registry and Database
Completed NCT02878148 - Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic N/A