Subcostal TAP Block For Percutaneous Nephrolithotomy

Status Completed

Clinical Trial Summary

Percutaneous nephrolithotomy (PCNL) is a minimally- invasive procedure for removing kidney stones. The small incision of PCNL is performed medially from the posterior axillary line according to stones location. Despite the small skin incision patients suffer from postoperative pain due to visceral pain and intercostal nerve injury. The aim of this study is to evaluate the perioperative analgesic effect of subcostal transversus abdominis plane (TAP) block performed prior to PCNL procedure.

Primary outcome of our study was Morphine consumption at 48th hour after the surgery. Secondary outcomes were perioperative fentanyl consumption; postoperative Verbal Analog Scale and additional analgesic drug requirement.

Clinical Trial Description

Patients who were scheduled for elective percutaneous nephrolithotomy were randomized into two groups: Group TAP and Group IV. General anesthesia was induced with propofol 2 mg/kg, fentanyl 1 mcgr/kg and rocuronium 0,6 mg/kg and maintained with sevoflurane 2% in 40%:60% oxygen/air mixture and fentanyl 0,5 mcgr/kg and rocuronium 10 mg, if necessary. Unilateral Transversus abdominis plane block was performed with total of 30 ml volume of local anesthetic solution (20ml Bupivacaine 0,125% and 10ml Lidocaine 1%) after intubation but before surgery to the Group TAP patients. Paracetamol 1 gr, iv was given to the Group IV 20 minutes before the end of the surgery. Also 100mg Tramadol,iv was administered 20 minutes before the end of the surgery to the both groups. Morphine iv patient controlled analgesia was applied to both groups. Perioperative fentanyl consumption; postoperative Verbal Analog Scale, morphine consumption and additional analgesic drug requirement were determined. Data of perioperative complications and adverse effects were also collected. Chi square with Yates correction and Mann Whitney U tests were used for statistical analysis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03454139
Study type	Interventional
Source	Istanbul University
Contact
Status	Completed
Phase	N/A
Start date	October 2015
Completion date	September 2017

View Details

See also
Status	Clinical Trial	Phase
Enrolling by invitation	`NCT04746378` - PRedictive Accuracy of Initial Stone Burden Evaluation.
Recruiting	`NCT05100017` - Methocarbamol vs Oxybutynin for Management of Pain and Discomfort S/P Ureteroscopy Procedure	N/A
Recruiting	`NCT03692715` - Antibiotic Prophylaxis Before Shock Wave Lithotripsy	Phase 4
Completed	`NCT02547805` - Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days	Phase 2
Completed	`NCT02289755` - Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria	Phase 2
Completed	`NCT01690039` - Influence of Polymorphisms in the ATP6V1 Gene of the V-ATPase on the Development of Incomplete Distal Renal Tubular Acidosis
Completed	`NCT01650935` - Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria	N/A
Completed	`NCT01295879` - Vitamin D Repletion in Stone Formers With Hypercalciuria	Phase 4
Recruiting	`NCT05014178` - Kidney Sodium Functional Imaging
Not yet recruiting	`NCT06199102` - The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.	N/A
Recruiting	`NCT04374188` - Efficacy of Ciprofloxacin Therapy in Avoidance of Sepsis in Patient Undergoing Percutanous Nephrolithotomy	N/A
Recruiting	`NCT04367155` - Efficacy of Tranexamic Acid on Blood Loss During Percutaneous Nephrolithotomy.	N/A
Recruiting	`NCT05701098` - SOUND Pivotal Trial - (Sonomotion stOne comminUtion resoNance ultrasounD)	N/A
Recruiting	`NCT04389853` - Mini-PNCL vs fURS in Management of Nephrolithiasis	N/A
Completed	`NCT03348228` - Effect of Hydroxycitrate on Urine Chemistry	N/A
Completed	`NCT05350423` - Trial Assessing Renal Damage During Ureteroscopy	N/A
Recruiting	`NCT02279927` - Prospective Comparison Between Different Laser Settings for Ureteral \ Kidney Stones Treatment During Ureteroscopy	N/A
Completed	`NCT02276924` - Diagnostic Relevance of Laser Confocal Microscopy for the Screening of Upper Urinary Tract Tumors	N/A
Completed	`NCT00159393` - Percutaneous Nephrolithotomy: A Registry and Database
Completed	`NCT02878148` - Conditional Imaging Prescription Strategy for Exploration of Acute Uncomplicated Renal Colic	N/A