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NCT01300039 Clinical Trial

Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

Nephrolithiasis Clinical Trial

Official title:
Oral Antibiotic Treatment of Helicobacter Pylori Reduces Intestinal Colonization Rates With Oxalobacter Formigenes

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT01300039
Other study ID # 573
Secondary ID
Status Completed
Phase N/A
First received February 18, 2011
Last updated February 18, 2011
Start date January 2003
Est. completion date June 2008

Study information
Verified date February 2011
Source VA New York Harbor Healthcare System
Contact n/a
Is FDA regulated No
Health authority United States: Federal Government
Study type Observational

Clinical Trial Summary

The investigators are finding out if giving antibiotics for Helicobacter pylori will eliminate colonization of the colon by Oxalobacter formigenes.

Description:

Background and objectives: Oxalobacter formigenes (OF) may play a protective role in preventing calcium oxalate stones. Intestinal colonization by OF is associated with reduced urinary oxalate excretion. Exposure to antibiotics may be an important factor contributing to variable rates of colonization. This is the first prospective study to evaluate the effect of antibiotics on OF colonization.

Design, setting, participants, & measurements: The effect of antibiotics on OF colonization was compared in 2 groups: a group receiving antibiotics for gastric infection with Helicobacter pylori (HP) and a group without HP that not receiving antibiotics. OF colonization in stool was detected by oxalate degradation at baseline and after 1 and 6 months.

Recruitment information / eligibility
Status Completed
Enrollment 50
Est. completion date June 2008
Est. primary completion date June 2008
Accepts healthy volunteers No
Gender Both
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria:

- age 18-80 years old

- undergoing upper endoscopy

- H. pylori present or absent on gastric histology

- stool positive for Oxalobacter formigenes

Exclusion Criteria:

- unable to consent

- stool negative for Oxalobacter formigenes

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
VA New York Harbor Healthcare System
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