Anesthesia and Acute Kidney Injury After Nephrectomy

Nephrectomy Clinical Trial

Official title:

The Influence of Type of Anesthesia on Postoperative Renal Function After Nephrectomy: a Randomized Controlled Study

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04474600
• Other study ID #: Anesthetics_Nx_AKI
• Status: Recruiting
• Phase: N/A
• Start date: July 20, 2020
• Est. completion date: March 2024

Study information

• Verified date: January 2024
• Source: Seoul National University Hospital
• Contact: Hyun-Kyu Yoon, MD
• Phone: +821095188501
• Email: hyunkyu18[@]gmail.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

This study investigates the influence of type of anesthesia on postoperative renal dysfunction in patients undergoing nephrectomy. The participants will be allocated to either the group receiving the total intravenous anesthesia (TIVA) using propofol or the group receiving the inhaled anesthetics using desflurane.

Description:

Nephrectomy is considered as a standard therapy for renal cell carcinoma, but it can cause postoperative renal dysfunction, such as acute kidney injury and chronic kidney disease. Therefore, it is imperative to identify modifiable risk factors for postoperative acute kidney injury after nephrectomy in advance. According to a recent retrospective study, total intravenous anesthesia using propofol is significantly associated with lower incidence of acute kidney injury after nephrectomy, compared to the inhalation anesthesia. However, there is no prospective study which investigates the influence of type of anesthesia on postoperative renal function after nephrectomy. Therefore, in the present study, we aimed to investigate the influence of type of anesthesia on acute kidney injury after nephrectomy by performing randomized controlled study.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 324
• Est. completion date: March 2024
• Est. primary completion date: February 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults patients scheduled for elective open nephrectomy

Exclusion Criteria:

• Patients diagnosed with acute kidney injury preoperatively

• Patients who have chronic kidney disease over stage 5 (estimated glomerular filtration rate [eGFR] <15 ml/kg/1.73m2) or have regular hemodialysis preoperatively

Related Conditions & MeSH terms

• Acute Kidney Injury
• Nephrectomy

Intervention

Drug:
• Propofol
The induction and maintenance of anesthesia was performed by total intravenous anesthesia using propofol. In both groups, remifentanil is continuously infused throughout the surgery.
• Desflurane
The induction and maintenance of anesthesia was performed by inhalation anesthesia using desflurane. In both groups, remifentanil is continuously infused throughout the surgery.

Locations

Country	Name	City	State
Korea, Republic of	Seoul National University Hospital	Seoul

Sponsors (1)

Lead Sponsor	Collaborator
Seoul National University Hospital

Country where clinical trial is conducted

Korea, Republic of, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	the incidence of acute kidney injury	acute kidney injury (diagnosed by KDIGO criteria)	during the postoperative seven days
Secondary	serum creatinine	postoperative result of serum creatinine	postoperative day 1, 3, 14
Secondary	estimated glomerular filtration rate	postoperative result of estimated glomerular filtration rate	postoperative day 1, 3, 14
Secondary	biomarker of renal injury	postoperative result of biomarker of renal injury	postoperative day 1, 3, 14
Secondary	the incidence of postoperative complications	urine leakage, prolonged ileus, wound infection, retroperitoneal abscess, pneumonia, reoperation, etc.	during the postoperative two weeks
Secondary	Length of hospital stay	length of hospital stay	during the postoperative two weeks
Secondary	Length of intensive care unit stay	length of intensive care unit stay	during the postoperative two weeks