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Neovascularization, Pathologic clinical trials

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NCT ID: NCT05969418 Completed - Clinical trials for Macular Degeneration Choroidal Neovascularization

Deep Learning Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) in NVC

OCTA
Start date: July 1, 2023
Phase:
Study type: Observational

To evaluate the activity of neovascular macula degeneretion as assessed by SD-OCTand OCT-A using a split-person study design and deep-learning quantification.

NCT ID: NCT05677685 Completed - Clinical trials for Diabetic Macular Edema

VISUPRIME® Eye Drops

Start date: June 22, 2023
Phase: N/A
Study type: Interventional

The study purpose is to assess the efficacy of VISUPRIME® eye drops in preventing the conjunctival bacterial load in patients undergoing to anti-VEGF injection.

NCT ID: NCT05662943 Completed - Clinical trials for Age-Related Macular Degeneration

Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCV

Start date: December 5, 2022
Phase:
Study type: Observational

The purpose of the present study was to evaluate the outcomes of type 1 macular neovascularization (MNV), including polypoidal choroidal vasculopathy in patients treated tolerating subretinal fluid (SRF) using Aflibercept in a clinical setting. Approximately 150 patients are anticipated to be enrolled in this study. SRF is a primary type of fluid compartment prevalent in type 1 aneurysmal MNV. In a recent study, the prevalence of SRF during 24-month follow-up period was 36.7% to 38.8% in type 1 MNV and polypoidal choroidal vasculopathy (PCV), 20.0% in type 2 MNV, and 7.7% in type 3 MNV. In addition, patients with SRF showed better visual prognosis in type 1 MNV/PCV. For this reason, type 1 MNV is an appropriate candidate for evaluating the influence of tolerating SRF.

NCT ID: NCT05295563 Completed - Cerebral Palsy Clinical Trials

Effects of Repeated Botulinum Toxin Injections in Children With Cerebral Palsy

Start date: May 1, 2021
Phase:
Study type: Observational

One of the disorders observed in children with cerebral palsy (CP) is abnormal muscle tone, and the most common tone problem is spasticity. Botulinum toxin A (BoNT-A) injections are frequently used to reduce spasticity in CP rehabilitation. BoNT-A injections can be administered as a single dose, and some patients require repeated injections. The aim of this study was to examine the effects of repeated BoNT-A applications applied to the gastrocnemius muscle of children with CP on muscle morphology and functionality.

NCT ID: NCT05108285 Completed - Clinical trials for Macular Neovascularisation

Dark Halo and MNV: a Study Between ICGA and OCTA

Start date: January 1, 2018
Phase:
Study type: Observational

The aim of study is to compare the evaluation of dark halo area of macular neovascularization (MNV) between indocyanine green angiography (ICGA) and optical coherence tomography angiography (OCTA) in order to identify OCTA as effective and useful biomarker in MNV

NCT ID: NCT04782271 Completed - Clinical trials for Choroidal Neovascularization

Safety, Tolerability and Pharmacokinetic Profile of SYL1801 Eye Drops

Start date: March 17, 2021
Phase: Phase 1
Study type: Interventional

Study of the safety, tolerability and pharmacokinetic profile of different doses of SYL1801 eye drops in healthy volunteers.

NCT ID: NCT04650672 Completed - Clinical trials for Retinal Neovascularization

Daily Testing at Home by NV-AMD Subjects With Notal Home OCT.

Start date: December 8, 2020
Phase:
Study type: Observational

The purpose of this study is to evaluate the ability of subjects with NV-AMD to perform sequential daily self-imaging of their eyes with the self-operated Notal Home OCT device in their homes for 90 days without on-site supervision. The study will include up to 15 subjects.

NCT ID: NCT04541316 Completed - Inguinal Hernia Clinical Trials

Neo-angiogenesis in Inguinal Henia Implant ProFlor

Start date: January 2013
Phase:
Study type: Observational

The investigation is aimed at specifically demonstrating the ingrowth of newly formed vascular elements within ProFlor, a 3D dynamic responsive implant for inguinal hernia repair

NCT ID: NCT04524910 Completed - Clinical trials for Myopic Choroidal Neovascularization

A Study to Learn More About How Drug Aflibercept Works in Canadian Patients With Reduced Vision Caused by New Blood Vessels Growing in the Eye (Myopic Choroidal Neovascularization or mCNV)

REALM
Start date: June 16, 2021
Phase:
Study type: Observational

Being short sighted means that vision is blurry when looking at things far away. People with a condition called "pathologic myopia" are short sighted due to problems in the back layer of their eyes, also known as the retina. Some people with pathologic myopia can develop a serious condition called myopic choroidal neovascularization (mCNV). In people with mCNV, new blood vessels grow into the retina. These blood vessels can break, leaking blood or fluid into the retina. This can cause blurry vision or a loss of vision. In this study, researchers will find out more about how well drug aflibercept works and how safe it is in Canadian patients with mCNV. The researchers in this study will review information from the patients' eye doctor visits. The patients in this study will include Canadian men and women who started receiving aflibercept between May 2017 and August 2019. These patients were at least 18 years old and had not received treatment for their mCNV before. The researchers will look at the results of vision tests to find out how well the patients could read from a distance after they received aflibercept for 6 months. They will compare the results of these tests to before the patients received treatment. They will also learn more about how safe it is to have aflibercept injection into the eye.

NCT ID: NCT04459195 Completed - Clinical trials for Muscle Stretching Exercises

Acute Effects of Static Stretching Duration on Gastrocnemius Muscle Vascularization

Start date: July 10, 2020
Phase: N/A
Study type: Interventional

Stretching effects skeletal muscle flexibility, vascularity and physical performance. The aim of our study is to examine the acute effects of static stretching duration on gastrocnemius muscle vascularization in healthy participants by superb microvascular imaging (SMI) and to compare the effects of 2 and 5 minutes of static stretching on blood flow.