Neoplasms Clinical Trial
Official title:
Clinical Evaluation of 18F-FAPI-RGD PET/CT for Imaging of Fibroblast Activation Protein and Integrin avb3 in Various Tumor Types
The clinical feasibility of 18F-FAPI-RGD PET/CT will be evaluated in 100 patients with various types of tumor, and the results will be compared with those of 18F-FDG.
Status | Recruiting |
Enrollment | 100 |
Est. completion date | October 2024 |
Est. primary completion date | September 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 10 Years to 80 Years |
Eligibility | Inclusion Criteria: - Patients with clinically suspected or diagnosed tumors Exclusion Criteria: - Hypertension that is difficult to control with medication, and systolic blood pressure exceeding 160mmHg - Complicated with chronic liver disease, myocardial infarction, stroke - Female patients who are pregnant (or attempting to become pregnant within six months), breastfeeding, or unwilling to use contraception - Abnormal cardiopulmonary function or mental state, unable to tolerate prone lying for 20 minutes |
Country | Name | City | State |
---|---|---|---|
China | Departments of Nuclear Medicine, Sichuan Provincial People's Hospital | Chengdu | Sichuan |
Lead Sponsor | Collaborator |
---|---|
Sichuan Provincial People's Hospital |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Comparison of 18F-FAPI-RGD and 18F-FDG Uptake in Patients with different Tumors | Tracer uptake in normal organs (background) is quanti?ed by SUVmean, which is delineated with a sphere that had a diameter of 1 cm (for small organs, including thyroid, salivary gland, and pancreas) to 2 cm(for other organs, including brain, heart, liver, kidney, spleen, muscle, and bone marrow) placed inside the organ parenchyma. The tumor-to background ratio (TBR) is calculated as tumor SUVmax/background SUVmean. | 1 month |
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