Measuring the Electrical Properties of Malignant Tissues In Vivo

Neoplasms Clinical Trial

Official title:

Measuring the Electrical Properties of the Malignant Tissues During Cancer Surgeries

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT02747225
• Other study ID #: SXXin-EPs-measurement-in vivo
• Status: Not yet recruiting
• Start date: December 2018
• Est. completion date: December 2020

Study information

• Verified date: October 2018
• Source: Southern Medical University, China
• Contact: Sherman X Xin, professor
• Phone: 008613602733465
• Email: xxg[@]smu.edu.cn
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

Previously published studies have indicated that there exist difference in electrical properties (EPs), i.e., the conductivity and relative permittivity, between malignant and adjacent normal tissue, which will be useful in the early detection of cancers. However the EP information mainly based on ex vivo measurement of cancer tissues, and few data in vivo were published. The purpose of this study is to in vivo measure the electrical properties of the malignant tissues.

Description:

The measurements were safety guaranteed and were conducted during the cancer surgeries. Before the tissue was excised from the patient,the pathologist assisted the operator (already at the operating room) responsible for the measurement.The measurement of malignant and corresponding normal tissues were both performed. The tissues for dielectric properties measurement were classified as normal or malignant by the pathologist based on his own expertise and decision criteria (visual inspection, anatomy) and the per-operative histological examination. The measurements were directly performed on the tissue before excision.The sites of the measured malignant tissues were marked,doubletracked according to the pathological report to make sure the marked sites are malignant. The patient age and tissue temperature at the time of measurement were recorded.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 50
• Est. completion date: December 2020
• Est. primary completion date: June 2019
• Accepts healthy volunteers: No
• Gender: All
• Age group: N/A and older

Eligibility

Inclusion Criteria:

• Clinical diagnosis of cancer Disease

Exclusion Criteria:

Related Conditions & MeSH terms

• Neoplasms

Intervention

Device:
• network analyzer
The dielectric properties of the tissues were measured using the open-ended coaxial line method. The measurement system consisted of a network analyzer (Model 4395A, Agilent Corp., Santa Clara, CA) associated with an S-parameter test set (Model 87511A, Agilent Corp., Santa Clara, CA). A semi-rigid coaxial line with a diameter of 3.58 mm was connected to the network analyzer system by using a Bayonet Neill-Concelman connector. The other tip of the coaxial line (probe) was placed on the flat bare surface of the tissue.

Locations

Country	Name	City	State
China	Southern medical university	Guangzhou	Guangdong

Sponsors (3)

Lead Sponsor	Collaborator
Southern Medical University, China	Nanfang Hospital of Southern Medical University, Zhujiang Hospital

Country where clinical trial is conducted

China, 

References & Publications (5)

Athey T W, Stuchly M A and Stuchly S S. Measurement of radio frequency permittivity of biological tissues with an open-ended coaxial line: Part I. Microwave Theory and Techniques, IEEE Transactions on IEEE Trans 30(1): 82-86, 1982.

Bobowski Jake S, Johnson Thomas. Permittivity measurements of biological samples by an open-ended coaxial line. Progress In Electromagnetics Research B 40: 159-183, 2012.

Mehta P, Chand K, Narayanswamy D, Beetner D G, Zoughi R and Stoecker W V. Microwave reflectometry as a novel diagnostic tool for detection of skin cancers IEEE Trans. Instrum. Meas. 55: 1309-16, 2006

Smith SR, Foster KR, Wolf GL. Dielectric properties of VX-2 carcinoma versus normal liver tissue. IEEE Trans Biomed Eng. 1986 May;33(5):522-4. — View Citation

Surowiec AJ, Stuchly SS, Barr JB, Swarup A. Dielectric properties of breast carcinoma and the surrounding tissues. IEEE Trans Biomed Eng. 1988 Apr;35(4):257-63. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Conductivity of the Malignant Tissues measured In Vivo		one year
Primary	Relative Permittivity of the Malignant Tissues measured In Vivo		one year

External Links

•   An Internet resource for the calculation of the dielectric properties of body tissues in the frequency range 10 Hz - 100 GHz Based on data published by C.Gabriel et al. in 1996.