Neoplasms Clinical Trial
Official title:
The Effect of Resistance Training and Aerobic Training on Body Composition During Chemotherapy
Chemotherapy can induce muscle loss in colorectal, breast and advanced renal cell carcinoma
patients. The Danish nation-wide training and rehabilitation offer 'Body & Cancer' offers
intensive resistance and endurance training to all Danish cancer patients receiving
chemotherapy with the aim of reducing treatment-related fatigue and physical impairments, but
the potential of the training to preserve or improve muscle mass is uninvestigated.
Furthermore, the underlying biological mechanisms of treatment and/or exercise induced
changes in muscle mass in cancer patients remains uninvestigated.
Thus, the primary purpose of the present study is to investigate changes in body composition
during chemotherapy and after resistance and aerobic training combined with protein
supplementation during ongoing chemotherapy in cancer patients. Secondly, we aim to
investigate the underlying biological mechanisms of muscle mass regulation in biopsies
obtained before and after a control period as well as after 10 weeks of exercise, both during
chemotherapy.
We hypothesize that 10 weeks exercise will improve muscle mass and body composition in cancer
patients during chemotherapy as compared to a control period during chemotherapy alone.
n/a
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