Neoplasms Clinical Trial
Official title:
A Phase I, Non-randomized Open-label Study to Evaluate the Effect of BAY73-4506 (Regorafenib) on Probe Substrates of CYP 2C9 (Warfarin), 2C19 (Omeprazole) and 3A4 (Midazolam) in a Cocktail Approach (Group A) and on a Probe Substrate of CYP 2C8 (Rosiglitazone, Group B) in Patients With Advanced Solid Tumors
- To evaluate the effect of BAY73-4506 on the pharmacokinetics of probe substrates of CYP
2C9 (warfarin), 2C19 (omeprazole) and 3A4 (midazolam) administered in a cocktail
approach and on the pharmacokinetics of a probe substrate of CYP 2C8 (rosiglitazone)
- To evaluate safety, anti-tumor activity, pharmacokinetics, and pharmacodynamics of
BAY73-4506 in patients with advanced solid tumors
n/a
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