Neoplasms Clinical Trial
Official title:
Pharmacodynamic Study of Axitinib in Patients With Advanced Solid Malignancies
The main purpose of this study is to see what changes happen to the tumors while taking the
axitinib and after it is stopped (during the scheduled breaks), and what changes in the tumor
may be responsible for this growth. This will be done by using a special kind of scan called
an 18F-FLT PET/CT.
In addition, the investigators want to find out how the drugs are processed and distributed
in the human body. The investigators will also look at how different types of cancer are
affected by axitinib. The investigators will also correlate vasculature kinetics extracted
from the dynamic FLT PET/CT imaging with the vasculature kinetics extracted from DCE-CT.
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