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Clinical Trial Summary

This study will evaluate PF-05212384 (gedatolisib) PI3K/mTOR inhibitor)) in combination with either docetaxel, cisplatin or dacomitinib in select advanced solid tumors. The study will assess the safety, pharmacokinetics and pharmacodynamics of these combinations in patients with advanced cancer in order to determine the maximum tolerated dose in each combination. The cisplatin combination expansion portion will evaluate the anti tumor activity of PF 05212384 plus cisplatin in patients with TNBC in 2 separate Arms (Arm 1 and Arm 2).


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT01920061
Study type Interventional
Source Pfizer
Contact
Status Completed
Phase Phase 1
Start date September 10, 2013
Completion date January 8, 2020

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