Necrotizing Enterocolitis Clinical Trial
Official title:
Intragastric and Intraperitoneal Microdialysis in Infants With NEC
NEC is a serious inflammatory bowel disease, which almost only strikes infants with low birth weight and low gestational age. The morbidity and mortality rates are high, and early diagnosis and treatment is mandatory. The primary aim of the present study is to investigate the clinical use of intragastric microdialysis and whether it is able to select patients, who may benefit from either medical or surgical therapy. The aim of intraperitoneal microdialysis is to evaluate whether changes in intraperitoneal microdialysis reflect the clinical outcome after laparotomy.
Neonates who are hospitalized because of suspicion of NEC are subjected to intragastric
microdialysis during the observation period. The catheter is placed in the stomach via the
naso-oesophageal route. If surgery is necessary a microdialysis catheter is placed in the
peritoneal cavity prior to wound closure. Samples are collected every 4-hour. Samples will
be analyzed continuously but the results will not be included in the clinical evaluation of
the patient.
A total of 20 patients will be included in this pilot study. The results of the intragastric
and peritoneal microdialysis will be compared with the clinical course, s-lactate,
radiological and pathological findings in each patient.
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Observational Model: Cohort, Time Perspective: Prospective
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