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Envafolimab Combined With Chemoradiotherapy and Recombinant Human Endostatin for LA-NPC.

Nasopharyngeal Carcinoma Clinical Trial

Official title:
A Prospective, Single-arm, Phase II Study of Envafolimab Combined With Chemoradiotherapy and Recombinant Human Endostatin in Locally Advanced Nasopharyngeal Carcinoma.

Clinical Trial Summary

This is a single-center, prospective, single-arm, phase II clinical study, with the purpose to evaluate the therapeutic efficacy and safety of envafolimab combined with chemoradiotherapy and recombinant human endostatin in patients with locally advanced nasopharyngeal carcinoma.

Clinical Trial Description

Patients with locally advanced nasopharyngeal carcinoma will receive 3 cycles of induction therapy with envafolimab combined with recombinant endostatin and gemcitabine and cisplatin, followed by 2 cycles of sequential envafolimab and recombinant human endostatin combined with radiotherapy alone in the low-risk group (with undetectable EBV DNA and CR/PR after induction therapy), or 2 cycles of sequential envafolimab and recombinant human endostatin combined with concurrent chemoradiotherapy in the high-risk group (with detectable EBV DNA or SD/PD after induction therapy), and finally 5 cycles of adjuvant therapy with envafolimab. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06059261
Study type Interventional
Source Chongqing University Cancer Hospital
Contact Xin Zhang, Ph.D, M.D.
Phone 18323063006
Email zhangxin9964@126.com
Status Not yet recruiting
Phase Phase 2
Start date October 1, 2023
Completion date October 1, 2027
View Details
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