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Interleukin-11 Can Prevent and Treat of Radioactive Oral Mucitis

Nasopharyngeal Carcinoma Clinical Trial

Official title:
The Open and Multi-center Phase III Clinical Study of Interleukin-11 in the Prevention and Treatment of Radioactive Oral Mucitis

Clinical Trial Summary

Radiation induced oral mucositis which may result in reduced quality of life is commonly seen during radiotherapy, especially combined with chemotherapy. This study is a prospective, multicenter, and exploratory study. The aim of this study is to explore predictive factors of acute radiotherapy induced oral mucositis in nasopharyngeal carcinoma patients treated with radio-chemotherapy and reduce incidence of oral mucositis by using recombinant human interleukin -11.

Clinical Trial Description

All nasopharyngeal patients received radical treatment including neo-adjuvant chemotherapy and concurrent chemo-radiotherapy. Oral pharyngeal swabs and stool specimen were collected 3times:before neo-adjuvant chemotherapy,before concurrent chemo-radiotherapy and concurrent chemo-radiotherapy finishied. Patients were randomly divided into two groups randomly. IL-11 was used in experience group and control group, saline. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03720340
Study type Interventional
Source Zhejiang Cancer Hospital
Contact
Status Recruiting
Phase Phase 3
Start date October 1, 2018
Completion date August 30, 2022
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