Nasolacrimal Duct Obstruction Clinical Trial
— NLD1Official title:
A Prospective Study of Primary Surgical Treatment of Nasolacrimal Duct Obstruction in Children Less Than Four Years Old
Verified date | January 2010 |
Source | Jaeb Center for Health Research |
Contact | n/a |
Is FDA regulated | No |
Health authority | United States: Federal Government |
Study type | Observational |
The purpose of this study is:
- To report the success proportions of simple probing within different age groups of
patients under 24 months of age.
- To obtain descriptive data regarding symptoms and quality of life in patients receiving
simple probing.
- To obtain similar data for simple probing in patients 24 months of age or older, for
intubation in patients age 6 - <48 months, and for balloon catheter dilation in
patients age 6 - <48 months.
Status | Completed |
Enrollment | 973 |
Est. completion date | September 2006 |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 6 Months to 47 Months |
Eligibility |
Inclusion Criteria: - Age 6 - < 48 months - Parent/guardian has the ability to complete a written questionnaire - For patients with two eyes requiring surgery at enrollment: investigator is planning to perform the same type of surgical procedure on both eyes - Onset of NLDO symptoms and/or signs prior to 6 months chronological age - Presence of epiphora, increased tear film, and/or mucopurulent discharge in the absence of an upper respiratory infection or an ocular surface irritation - Undergoing primary NLDO surgery Exclusion Criteria: - History of nasolacrimal duct surgery including simple probing, nasolacrimal intubation, balloon catheter dilation, or dacryocystorhinostomy - Glaucoma present - Corneal surface disease |
Observational Model: Cohort, Time Perspective: Prospective
Country | Name | City | State |
---|---|---|---|
United States | Wilmer Eye Institute | Baltimore | Maryland |
United States | Family Eye Clinic | Lancaster | Pennsylvania |
Lead Sponsor | Collaborator |
---|---|
Jaeb Center for Health Research | National Eye Institute (NEI) |
United States,
Pediatric Eye Disease Investigator Group, Repka MX, Chandler DL, Beck RW, Crouch ER 3rd, Donahue S, Holmes JM, Lee K, Melia M, Quinn GE, Sala NA, Schloff S, Silbert DI, Wallace DK. Primary treatment of nasolacrimal duct obstruction with probing in children younger than 4 years. Ophthalmology. 2008 Mar;115(3):577-584.e3. Epub 2007 Nov 8. — View Citation
Pediatric Eye Disease Investigator Group, Repka MX, Melia BM, Beck RW, Chandler DL, Fishman DR, Goldblum TA, Holmes JM, Perla BD, Quinn GE, Silbert DI, Wallace DK. Primary treatment of nasolacrimal duct obstruction with balloon catheter dilation in children younger than 4 years of age. J AAPOS. 2008 Oct;12(5):451-5. doi: 10.1016/j.jaapos.2008.07.001. — View Citation
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT00780741 -
Immediate Office Probing vs Deferred Facility Probing for Nasolacrimal Duct Obstruction in Children 6 to <10 Months Old
|
Phase 3 | |
Completed |
NCT00784992 -
A Comparison of Endonasal Dacryocystorhinostomy With and Without Silicone Tubes
|
Phase 4 | |
Recruiting |
NCT06346561 -
The Efficacy of Dexmedetomidine Versus Labetalol In Providing Controlled Hypotension In Dacryocystorhinostomy SurgeryA Comparative Randomized Prospective Study
|
N/A | |
Completed |
NCT01233596 -
Monocanalicular Versus Bicanalicular Intubation in the Treatment of Congenital Nasolacrimal Duct Obstruction
|
Phase 3 | |
Recruiting |
NCT06226181 -
Amniotic Membrane for Dacryocystorhinostomy
|
Phase 1 | |
Completed |
NCT00315315 -
Study of Surgical Procedures for Treatment of Persistent Nasolacrimal Duct Obstruction in Children < 4 Years Old
|
Phase 3 | |
Recruiting |
NCT05999630 -
Artificial Tears to Prevent Nasolacrimal Duct Obstruction in Patients Treated With Radioactive Iodine for Thyroid Cancer
|
Phase 3 | |
Completed |
NCT01766232 -
Lacrimal Drainage Resistance Study
|
N/A |