Mint Tea for the Treatment of Nasal Polyps

Status Completed

Clinical Trial Summary

The purpose of this study is to evaluate the safety and efficacy of a new treatment for nasal polyps as compared to placebo (an inactive substance). The treatment involved is mint tea high in rosmarinic acid. Rosmarinic acid is a polyphenol, or a chemical substance found in certain plants such as oregano, rosemary, and the mints. It is the active ingredient in spearmint. The placebo used in this study will be mint tea low in rosmarininc acid. In this trial the amount of rosmarinic acid in the high rosmarinic acid tea, or study tea, will be 150mg. The placebo, or low rosmarinic acid tea, will contain 10mg of rosmarinic acid.

Clinical Trial Description

Nasal polyps are clear, glistening, grape-like structures that occur in two percent of adults and contain a large number of activated eosinophils - about 20% of the constituents of nasal polyp tissue.

The standard treatment for nasal polyp patients is intranasal steroids which, in troublesome cases, may follow a short course of oral steroids. Surgery is reserved for extremely large polyps and those who fail medical treatment. However, many patients tire of using nasal sprays or are troubled by side effects such as nasal irritation or bleeding. So, while all treatments offer some benefit, there is no gold standard.

Rosmarinic acid is categorized as a polyphenolia phytochemical, or a 'plant phenol' and is found in a variety of plants including the herbs oregano and rosemary, as well as the mints. Peppermint is one of the most widely used single ingredient in herbal teas. It has been found in vitro to have significant antimicrobial and antiviral properties, strong antioxidant and antitumor actions, and some antiallergenic ability. Human based research is limited.

A mint tea high in rosmarinic acid has recently been produced. Anecdotal evidence suggests that it may be beneficial for allergic rhinitis if taken prior to allergen exposure (personal communication). Other anecdotal evidence found a blunting of the sputum eosinophils following allergen challenge in allergic asthmatics (personal communication). This trial aims to study the effects of this mint tea high in rosmarinic acid in adults with bilateral nasal polyps, a condition characterized by chronic eosinophilic inflammation. The control treatment will be a mint tea low in rosmarinic acid. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00465543
Study type	Interventional
Source	McMaster University
Contact
Status	Completed
Phase	Phase 2
Start date	May 2007
Completion date	June 2008

View Details

See also
Status	Clinical Trial	Phase
Withdrawn	`NCT02071667` - Association of Periostin Levels and Chronic Sinusitis	N/A
Completed	`NCT01623310` - 12-Month OL Intranasal Fluticasone Propionate BID Using OptiNose Device	Phase 3
Completed	`NCT02024659` - Effects and Safety of Budesonide Inhalation Suspension Via Transnasal Nebulization in Nasal Polyps	Phase 2/Phase 3
Completed	`NCT00215787` - Investigation of the Association Between Nasal Polyposis and Extraesophageal Reflux Disease	N/A
Completed	`NCT04996576` - Infrazygomatic Versus Intranasal Injection Sphinopalatine Ganglion Blockade Effect on Surgical Field in FESS	N/A
Recruiting	`NCT03963648` - NO Measurements in Screening for Asthma and OSA, in Patients With CRSwNP	N/A
Recruiting	`NCT05094570` - Interleukin-4Ra Blockade by Dupilumab Decreases Staphylococcus Colonization and Increases Microbial Diversity in CRSwNP	Phase 4
Recruiting	`NCT05009758` - Moving Towards Precision Medicine in United Airways Disease: Unraveling Inflammatory Patterns in Asthmatic Patients With or Without Nasal Polyps	N/A
Completed	`NCT00731185` - Mometasone Furoate Nasal Spray for Treatment of Nasal Polyposis After Surgery (Study P03218)	Phase 3
Active, not recruiting	`NCT03943121` - The Effects of Steroid-eluting Stent Implant for the Treatment of Eosinophilic Chronic Rhinosinusitis With Nasal Polyps	N/A
Active, not recruiting	`NCT03704415` - Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)	N/A
Not yet recruiting	`NCT06070311` - Wound Healing After Endoscopic Sinus Surgery	N/A
Completed	`NCT02879929` - Development and Validity of the DyNaChron Questionnaire for Chronic Nasal Dysfunction	N/A
Recruiting	`NCT05672030` - Role of IL-5R Signaling in Non-eosinophil Upper Airway Cells in CRSwNP
Suspended	`NCT04261582` - Genetics and Genomics of Aspirin Exacerbated Respiratory Disease (AERD)
Recruiting	`NCT05063981` - Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma With or Without CRSwNP.
Completed	`NCT05180357` - RANS. Study in Patients With Severe Eosinophilic Asthma and Nasal Polyps.
Completed	`NCT00788463` - A Comparison of Beclomethasone Aqueous Spray and Aerosol Delivery Systems in Nasal Polyps	Phase 2
Completed	`NCT01198912` - Influence of Oral Doxycycline on Wound Healing After Endonasal Endoscopic Sinus Surgery for Chronic Rhinosinusitis With and Without Nasal Polyposis: a Double-blind Randomized Placebo-controlled Trial	Phase 2
Completed	`NCT03280537` - A Clinical Trial of Omalizumab in Participants With Chronic Rhinosinusitus With Nasal Polyps	Phase 3